Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines

被引：0

作者：

Khaled A. M. Abouzid

Nadia A. Khalil

Eman M. Ahmed

机构：

[1] Ain Shams University,Pharmaceutical Chemistry Department, Faculty of Pharmacy

[2] Cairo University,Organic Chemistry Department, Faculty of Pharmacy

来源：

Medicinal Chemistry Research | 2012年 / 21卷

关键词：

Breast cancer; Anti-proliferative activity; Phthalazine; Phthalazinone;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of new phthalazine derivatives 3a–i and 4a–c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a–c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 μmol.

引用

页码：3288 / 3293

页数：5

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