Development and clinical translation of photoacoustic mammography

被引：15
作者：
Shiina T. [1 ]
Toi M. [2 ]
Yagi T. [3 ]
机构：
[1] Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto
[2] Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto
[3] Japan Science and Technology Agency, ImPACT Program, Cabinet Office, K’s Gobancho, 7, Gobancho, Chiyoda-ku, Tokyo
来源：
Shiina, Tsuyoshi (shiina.tsuyoshi.6w@kyoto-u.ac.jp) | 2018年 / Springer Verlag卷 / 08期
基金：
日本学术振兴会;
关键词：
Mammography; Optoacoustic; Oxygen saturation; Photoacoustic imaging; Ultrasound; Vascularity;
D O I：
10.1007/s13534-018-0070-7
中图分类号：
学科分类号：
摘要：
To practically apply photoacoustic (PA) imaging technology in medicine, we have developed prototypes of a photoacoustic mammography (PAM) device to acquire images for diagnosing breast cancer in the Kyoto University/Canon joint research project (CK project supported by MEXT, Japan). First, the basic ability of the PAM system to visualize the network of blood vessels and the Hb saturation index was evaluated using a prototype of PAM that has a flat scanning detector and is capable of simultaneously acquiring photoacoustic (PA) and ultrasound images. Next, another prototype of a PAM device with hemispherical sensors was developed to improve the visibility of the 3D structure of vessels by reducing the limited view effect. In clinical examination of breast cancer cases, the PAM system allowed 3D visualization of fine vessel networks with a spatial resolution of a half-millimeter and enabled us to determine the features of tumor-related vascular structures in human breast cancer. In addition, the oxygen saturation status of Hb was visualized using two different wavelengths, enabling more precise characterization of the tumor microenvironment. Results of clinical evaluation using our developed prototype of a PAM device confirmed that PA imaging technology has the potential to promote early detection of breast cancer, and realization of its practical use is expected in the near future. © 2018, Korean Society of Medical and Biological Engineering and Springer-Verlag GmbH Germany, part of Springer Nature.
引用
收藏
页码：157 / 165
页数：8
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