Nonadherence to immunosuppressive therapy is a significant problem after solid-organ transplantation

被引：0

作者：

Kawaguchi S. ^{[1
,3
]}

Maniruzzaman M. ^{[1
]}

Katsuragi K. ^{[1
]}

Matsumoto H. ^{[1
]}

Iriany I. ^{[1
]}

Ito K. ^{[1
]}

Hugenberg N. ^{[1
,2
]}

Schmidt M. ^{[1
,2
]}

机构：

[1] Department of Materials Science, Toyohashi University of Technology, Tempaku-cho

[2] Institute of Physical Chemistry, University of Mainz, Mainz 55099

[3] Department of Polymer Science and Engineering, Faculty of Engineering, Yamagata University, Jonan

来源：

Drugs & Therapy Perspectives | 2002年 / 18卷 / 12期

关键词：

Adis International Limited; Transplant Recipient; Medication Adherence; Sirolimus; Renal Transplant Patient;

D O I：

10.2165/00042310-200218120-00007

中图分类号：

学科分类号：

摘要：

Nonadherence to immunosuppressive therapy after solid-organ transplantation can result in graft rejection, dialysis, decreased productivity, reduced quality of life, and increased morbidity, mortality and healthcare are frequently nonadherent to immunosuppressive therapy, with nonadherence rates ranging from 2 to 68% in studies of solid organ transplant recipients. Although numerous factors have been identified as being related to nonadherence to immunosuppresive treatment, such behaviour is generally not predictable. Factors influencing a patient's adherence to immunosuppressive therapy can be divided into 4 main categories: motivation, knowledge, skills to follow therapy, and access to care. Patient motivation represents the driving force of adherence to immunosuppressive therapy. Because of the potential adverse effects of nonadherence, it is important to increase medication compliance in all transplant recipients.

引用

页码：19 / 21

页数：2

共 11 条

[1]

Chisholm M.A., Issues of adherence to immunosuppressant therapy after solid-organ transplantation, Drugs, 62, 4, pp. 567-575, (2002)

[2]

Rovelli M., Palmeri D., Vossler E., Et al., Noncompliance in organ transplant recipients, Transplant Proc., 21, pp. 833-834, (1989)

[3]

Rovelli M., Palmeri D., Vossler E., Et al., Noncompliance in renal transplant recipients: Evaluation by socioeconomic groups, Transplant. Proc., 21, pp. 3979-3981, (1989)

[4]

Siegal B.R., Greenstein S.M., Postrenal transplant compliance from the perspective of African-Americans, Hispanic-Americans, Anglo-Americans, Adv. Ren. Replace Ther., 4, pp. 46-54, (1997)

[5]

Greenstein S., Siegal B., Compliance and noncompliance in patients with a functioning renal transplant: A multicenter study, Transplantation, 66, pp. 1718-1726, (1998)

[6]

Kiley D.J., Lam C.S., Pollack R., A study of treatment compliance following kidney transplantation, Transplantation, 55, pp. 51-56, (1993)

[7]

(2002)

[8]

Sketris I., Waite N., Grober K., Et al., Factors affecting compliance with cyclosporine in adult renal transplant patients, Transplant. Proc., 26, pp. 2538-2541, (1994)

[9]

Butkus D.E., Meydrech E.F., Raju S.S., Racial differences in the survival of cadaveric renal allografts: Overriding effects of HLA matching socioeconomic factors, N. Engl. J. Med., 327, pp. 840-845, (1992)

[10]

Stewart R.B., Caranasos G.J., Medication compliance in the elderly, Med. Clin. North Am., 73, pp. 1551-1563, (1989)

← 1 2 →