Efficacy of weekly docetaxel in locally advanced cardiac angiosarcoma

被引：8

作者：

Minichillo S. ^{[1
]}

Pantaleo M.A. ^{[1
,2
]}

Nannini M. ^{[1
,2
]}

Coccolo F. ^{[3
]}

Gatto L. ^{[1
]}

Biasco G. ^{[1
,2
]}

Brandi G. ^{[1
]}

机构：

[1] Department of Specialized, Experimental and Diagnostic Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti, 9, Bologna

[2] Giorgio Prodi Cancer Research Center, University of Bologna, Via Massarenti, 9, Bologna

[3] Cardiovascular Department, University of Bologna, Via Massarenti, 9, Bologna

来源：

BMC Research Notes | / 8卷 / 1期

关键词：

Angiosarcoma; Cardiac tumors; Docetaxel; Soft tissue sarcoma; Taxanes;

D O I：

10.1186/s13104-015-1296-4

中图分类号：

学科分类号：

摘要：

Background: Primary cardiac angiosarcoma is extremely aggressive; however, it is often misdiagnosed because of its rarity. For locally advanced tumors, doxorubicin-based chemotherapy regimens are the standard of treatment, even if the gain in term of progression-free survival is limited and is no longer than 5 months. Case presentation: We report the case of a Caucasian 23-year-old man with locally advanced cardiac angiosarcoma who underwent radical surgical resection after a prolonged response to weekly docetaxel and complementary radiotherapy. Conclusion: Combined treatment with weekly docetaxel and radiotherapy may be a valid alternative for the treatment of locally advanced cardiac angiosarcoma; the combination can lead to radical surgical resections, avoiding the cumulative cardiotoxicity of antracycline-based regimens. © 2015 Minichillo et al.

引用

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