Oxidative Mechanisms and Tardive Dyskinesia

被引：0
作者：
James B. Lohr
Ronald Kuczenski
Alexander B. Niculescu
机构：
[1] University of California San Diego,Department of Psychiatry
[2] VA San Diego Healthcare System,Psychiatry Service V
来源：
CNS Drugs | 2003年 / 17卷
关键词：
Melatonin; Haloperidol; Antipsychotic Medication; Tardive Dyskinesia; Selegiline;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Tardive dyskinesia has been and continues to be a significant problem associated with long-term antipsychotic use, but its pathophysiology remains unclear. In the last 10 years, preclinical studies of the administration of antipsychotics to animals, as well as clinical studies of oxidative processes in patients given anti-psychotic medications, with and without tardive dyskinesia, have continued to support the possibility that neurotoxic free radical production may be an important consequence of antipsychotic treatment, and that such production may relate to the development of dyskinetic phenomena.
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页码：47 / 62
页数：15
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