Obesity, diabetes, and chronic kidney disease

被引：60
作者：
Eknoyan G. [1 ]
机构：
[1] Renal Section, Department of Medicine (523-D), Baylor College of Medicine, Houston, TX 77030, One Baylor Plaza
来源：
Current Diabetes Reports | 2007年 / 7卷 / 6期
关键词：
Obesity; Chronic Kidney Disease; Diabetic Nephropathy; Urinary Albumin Excretion; Kidney Biopsy;
D O I：
10.1007/s11892-007-0076-5
中图分类号：
学科分类号：
摘要：
Similar to diabetes, obesity is associated with the early onset of glomerulomegaly, hemodynamic changes of a hyperfiltering kidney, and increased albuminuria, which are potentially reversible with weight loss, However, the pathologic lesions of focal segmental glomerulosclerosis in experimental models of sustained obesity, and in obese humans presenting with massive proteinuria, are different from those of classic diabetic nephropathy. In addition, several observational, cross-sectional, and longitudinal studies document obesity as an independent risk factor for the onset, aggravated course, and poor outcomes of chronic kidney disease, even after adjustment for confounding comorbidities, including diabetes and hypertension, the two major causes of chronic kidney disease. Copyright © 2007 by Current Medicine Group LLC.
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收藏
页码：449 / 453
页数：4
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