Cellular and molecular events leading to renal tubulointerstitial fibrosis

被引：165
作者：
Razzaque M.S. [1 ,2 ]
Taguchi T. [1 ]
机构：
[1] Second Department of Pathology, Nagasaki University School of Medicine, Nagasaki 852-8523
[2] Department of Oral Medicine, Harvard School of Dental Medicine, Boston, MA
来源：
Medical Electron Microscopy | 2002年 / 35卷 / 2期
关键词：
Fibrogenic factors; Fibrosis; Interstitium; Kidney; Tubules;
D O I：
10.1007/s007950200009
中图分类号：
学科分类号：
摘要：
Connective tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic process associated with both physiological responses, such as wound healing, and pathological conditions, such as renal tubulointerstitial fibrosis (TIF). Data from the published literature indicate that collagens and several non-collagenous ECM glycoproteins actively contribute to TIF. The early phase of TIF is usually associated with an inflammatory process mediated by soluble factors released by activated resident cells and by infiltrating cells. Fibrogenic cytokines and growth factors secreted by inflammatory cells and fibroblasts are actively involved in connective tissue remodeling, possibly by regulating the rate of synthesis and degradation of the ECM. An uncontrolled balance of this process usually results in TIF. We review the physiology of wound healing and the pathology of fibrosis, emphasizing TIF.
引用
收藏
页码：68 / 80
页数：12
相关论文
共 150 条
  • [1] Bin L., Connolly M.K., The pathogenesis of cutaneous fibrosis, Semin Cut Med Surg, 17, pp. 3-11, (1998)
  • [2] McCrudden R., Iredale J.P., Liver fibrosis, the hepatic stellate cell and tissue inhibitors of metalloproteinases, Histol Histopathol, 15, pp. 1159-1168, (2000)
  • [3] Badid C., Mounier N., Costa A.M., Desmouliere A., Role of myofibroblasts during normal tissue repair and excessive scarring: Interest of their assessment in nephropathies, Histol Histopathol, 15, pp. 269-280, (2000)
  • [4] Marikovsky M., Breuing K., Liu P.Y., Eriksson E., Higashiyama S., Farber P., Abraham J., Klagsbrun M., Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury, Proc Natl Acad Sci USA, 90, pp. 3889-3893, (1993)
  • [5] Seppa H., Grotendorst G., Seppa S., Schiffmann E., Martin G.R., Platelet-derived growth factor is chemotactic for fibroblasts, J Cell Biol, 92, pp. 584-588, (1982)
  • [6] Nissen N.N., Polverini P.J., Koch A.E., Volin M.V., Gamelli R.L., DiPietro L.A., Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing, Am J Pathol, 152, pp. 1445-1452, (1998)
  • [7] Tonnesen M.G., Feng X., Clark R.A., Angiogenesis in wound healing, J Invest Dermatol Symp Proc, 5, pp. 40-46, (2000)
  • [8] Takehara K., Growth regulation of skin fibroblasts, J Dermatol Sci, 24, SUPPL. 1, (2000)
  • [9] Schirren C.G., Scharffetter K., Hein R., Braun-Falco O., Krieg T., Tumor necrosis factor alpha induces invasiveness of human skin fibroblasts in vitro, J Invest Dermatol, 94, pp. 706-710, (1990)
  • [10] Liechty K.W., Crombleholme T.M., Cass D.L., Martin B., Adzick N.S., Diminished interleukin-8 (IL-8) production in the fetal wound healing response, J Surg Res, 77, pp. 80-84, (1998)
12345678910