Dental implant bioactive surface modifications and their effects on osseointegration: A review

被引：74

作者：

Meng H.-W. ^{[1
]}

Chien E.Y. ^{[2
]}

Chien H.-H. ^{[3
]}

机构：

[1] Department of Periodontics, University of Texas School of Dentistry at Houston, Houston, TX

[2] College of Dentistry, Ohio State University, Columbus, OH

[3] Division of Periodontology, College of Dentistry, Ohio State University, 305 West 12th Avenue, Columbus, 43210, OH

来源：

Biomarker Research | / 4卷 / 1期

关键词：

Bioactive surface modification; Dental implant; Osseointegration;

D O I：

10.1186/s40364-016-0078-z

中图分类号：

学科分类号：

摘要：

Background: The purpose of this article is to review and update the current developments of biologically active dental implant surfaces and their effect on osseointegration. Methods: PubMed was searched for entries from January 2006 to January 2016. Only in-vivo studies that evaluated the effects of biomolecular coatings on titanium dental implants inserted into the bone of animals or humans were included. Results: Thirty four non-review studies provided data and observations were included in this review. Within the criteria, four categories of biomolecular coatings were evaluated. The potential biomolecules include bone morphogenetic proteins in 8 articles, other growth factors in 8 articles, peptides in 5 articles, and extracellular matrix in 13 articles. Most articles had a healing period of 1 to 3 months and the longest time of study was 6 months. In addition, all studies comprised of implants inserted in animals except for one, which evaluated implants placed in both animals and humans. The results indicate that dental implant surface modification with biological molecules seem to improve performance as demonstrated by histomorphometric analysis (such as percentage of bone-to-implant contact and peri-implant bone density) and biomechanical testing (such as removal torque, push-out/pull-out tests, and resonance frequency analysis). Conclusions: Bioactive surface modifications on implant surfaces do not always offer a beneficial effect on osseointegration. Nevertheless, surface modifications of titanium dental implants with biomolecular coatings seem to promote peri-implant bone formation, resulting in enhanced osseointegration during the early stages of healing. However, long-term clinical studies are needed to validate this result. In addition, clinicians must keep in mind that results from animal experiments need not necessarily reflect the human clinical reality. © The Author(s). 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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