Electroacupuncture Pretreatment Attenuates Inflammatory Lung Injury After Cardiopulmonary Bypass by Suppressing NLRP3 Inflammasome Activation in Rats

被引：0
作者：
Dongxiao Huang
Mo Chen
Zhankui Wang
Lei Hou
Weifeng Yu
机构：
[1] The Third Affiliated Hospital of Soochow University,Department of Anesthesiology
[2] Wuxi People’s Hospital,Department of Orthopedics, The First Clinical Medical College
[3] Shaanxi University of Chinese Medicine,Department of Anesthesiology, Ren Ji Hospital, School of Medicine
[4] Shanghai Jiao Tong University,Department of Anesthesiology, Shanghai Eastern Hepatobiliary Surgery Hospital
[5] Second Military Medical University,undefined
来源：
Inflammation | 2019年 / 42卷
关键词：
Electroacupuncture; Inflammatory lung injury; Cardiopulmonary bypass; NLRP3; IL-1β; Caspase-1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cardiopulmonary bypass (CPB) can induce inflammatory lung injury, which is a common complication during cardiac surgery. Nod-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in lung injury after CPB. Previous studies have shown that electroacupuncture (EA) has potential anti-inflammatory activity. However, the role of EA in CPB is poorly understood. The aim of this study was to determine whether EA was associated with CPB-induced inflammatory lung injury. In the present study, rats were treated with EA for 5 days before CPB. Two hours after CPB, the lung tissue, serum, and bronchoalveolar lavage fluid (BALF) were prepared for assessment. Our results showed that the expression of NLRP3 in the lung tissue increased significantly after CPB. The EA pretreatment suppressed NLRP3 inflammasome activation, reduced lung edema, and inhibited IL-1β release into the serum and BALF after CPB. Our findings suggest that EA pretreatment attenuates inflammatory lung injury after CPB by suppressing NLRP3 inflammasome activation.
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页码：895 / 903
页数：8
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