Apoptosis in neurodegenerative disorders

被引:0
作者
Mark P. Mattson
机构
[1] Laboratory of Neurosciences,
[2] National Institute on Aging,undefined
[3] Gerontology Research Center,undefined
来源
Nature Reviews Molecular Cell Biology | 2000年 / 1卷
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摘要
Neuronal death underlies the symptoms of many human neurological disorders, including Alzheimer's, Parkinson's and Huntington's diseases, stroke, and amyotrophic lateral sclerosis. The identification of specific genetic and environmental factors responsible for these diseases has bolstered evidence for a shared pathway of neuronal death — apoptosis — involving oxidative stress, perturbed calcium homeostasis, mitochondrial dysfunction and activation of cysteine proteases called caspases. These death cascades are counteracted by survival signals, which suppress oxyradicals and stabilize calcium homeostasis and mitochondrial function. With the identification of mechanisms that either promote or prevent neuronal apoptosis come new approaches for preventing and treating neurodegenerative disorders.
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页码:120 / 130
页数:10
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共 235 条
[71]  
Zhou D(1995)Autoimmunity and ALS Neuron 14 1105-1116
[72]  
Bruce-Keller A J(1999)Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation Exp. Neurol. 160 28-39
[73]  
Kindy MS(2000)An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria Int. J. Mol. Med. 5 3-13
[74]  
Mattson MP(2000)ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis Science 288 335- 339
[75]  
Aschner M(1997)Mechanisms for neuronal degeneration in amyotrophic lateral sclerosis and in models of motor neuron death Science 277 559-562
[76]  
Allen JW(1999)Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model Trends Neurosci. 22 391- 397
[77]  
Kimelberg HK(1999)Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis Physiol. Rev. 79 1431-568
[78]  
LoPachin RM(1997)Pathobiology of ischaemic stroke: an integrated view Nature 390 622-625
[79]  
Streit WJ(1998)Ischemic cell death in brain neurons J. Cereb. Blood Flow Metab. 18 180 -185
[80]  
Yu ZF(1997)Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2 Proc. Natl Acad. Sci. USA 94 2007-2012