Altered proteolytic events in experimental autoimmune encephalomyelitis discovered by iTRAQ shotgun proteomics analysis of spinal cord

[1] Schaecher K(2002)Calpain expression and infiltration of activated T cells in experimental allergic encephalomyelitis over time: increased calpain activity begins with onset of disease J Neuroimmunol 129 1-9

[2] Rocchini A(2001)How matrix metalloproteinases regulate cell behavior Annu Rev Cell Dev Biol 17 463-516

[3] Dinkins J(2008)The multiple sclerosis degradome: enzymatic cascades in development and progression of central nervous system inflammatory disease Curr Top Microbiol Immunol 318 133-175

[4] Matzelle DD(2000)Chemical strategies for the global analysis of protein function Curr Opin Chem Biol 4 663-668

[5] Banik NL(2004)Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates Proc Natl Acad Sci USA 101 6917-6922

[6] Sternlicht MD(2007)Proteomic validation of protease drug targets: pharmacoproteomics of matrix metalloproteinase inhibitor drugs using isotope-coded affinity tag labelling and tandem mass spectrometry Curr Pharm Des 13 263-270

[7] Werb Z(2007)Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome Mol Cell Proteomics 6 611-623

[8] Scarisbrick IA(2005)Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis Nat Methods 2 771-777

[9] Cravatt BF(2008)Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini Cell 134 866-876

[10] Sorensen EJ(2007)Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord J Proteome Res 6 2565-2575

[1] Schaecher K(2002)Calpain expression and infiltration of activated T cells in experimental allergic encephalomyelitis over time: increased calpain activity begins with onset of disease J Neuroimmunol 129 1-9

[2] Rocchini A(2001)How matrix metalloproteinases regulate cell behavior Annu Rev Cell Dev Biol 17 463-516

[3] Dinkins J(2008)The multiple sclerosis degradome: enzymatic cascades in development and progression of central nervous system inflammatory disease Curr Top Microbiol Immunol 318 133-175

[4] Matzelle DD(2000)Chemical strategies for the global analysis of protein function Curr Opin Chem Biol 4 663-668

[5] Banik NL(2004)Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates Proc Natl Acad Sci USA 101 6917-6922

[6] Sternlicht MD(2007)Proteomic validation of protease drug targets: pharmacoproteomics of matrix metalloproteinase inhibitor drugs using isotope-coded affinity tag labelling and tandem mass spectrometry Curr Pharm Des 13 263-270

[7] Werb Z(2007)Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome Mol Cell Proteomics 6 611-623

[8] Scarisbrick IA(2005)Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis Nat Methods 2 771-777

[9] Cravatt BF(2008)Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini Cell 134 866-876

[10] Sorensen EJ(2007)Identification of differentially expressed proteins in experimental autoimmune encephalomyelitis (EAE) by proteomic analysis of the spinal cord J Proteome Res 6 2565-2575