Role of LKB1 in lung cancer development

被引：0
|
作者：
L Makowski
D N Hayes
机构：
[1] Sarah W Stedman Nutrition and Metabolism Center,Division of Endocrinology, Department of Medicine
[2] Duke University Medical Center,Division of Medical Oncology, Department of Internal Medicine
[3] Metabolism,undefined
[4] and Nutrition,undefined
[5] Lineberger Comprehensive Cancer Center,undefined
[6] University of North Carolina,undefined
来源：
British Journal of Cancer | 2008年 / 99卷
关键词：
LKB1; STK11; Peutz-Jeghers syndrome; review; lung cancer; heritable tumour syndromes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation.
引用
收藏
页码：683 / 688
页数：5
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