Phylogenetic and evolutionary analysis of foot-and-mouth disease virus A/ASIA/Sea-97 lineage

被引：0
作者：
Soyeon Bae
Vladimir Li
Juyong Hong
Jin Nam Kim
Heebal Kim
机构：
[1] Seoul National University,Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences
[2] Seoul National University,Interdisciplinary Program in Bioinformatics
[3] eGnome,undefined
[4] Inc,undefined
来源：
Virus Genes | 2021年 / 57卷
关键词：
Foot-and-mouth disease virus; Phylogenetic analysis; Bayesian analysis; Virus evolution;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Foot-and-mouth disease virus (FMDV) A/ASIA/Sea-97 is a predominant lineage in Southeast Asia and East Asia. However, Sea-97 lineage has not been well studied since its first outbreak in Thailand in 1997. Thus, we conducted phylogenetic and evolutionary analysis of Sea-97 using 224 VP1 sequences of FMDV A/ASIA during 1960 and 2018. Phylogenetic analysis revealed that Sea-97 lineage can be classified into five groups (G1–G5). After the emergence of G2 from G1, the genetic diversity of Sea-97 increased sharply, causing divergence into G3, G4 and G5. During this evolutionary process, Sea-97 lineage, which was initially found only in some countries in Southeast Asia, gradually spread to East Asia. The evolution rate of this lineage was estimated to be 1.2 × 10–2 substitutions/site/year and there were many differences in amino acid residues compared to vaccine strain. Substitutions at antigenically important sites may affect the efficacy of the vaccine, suggesting the need for appropriate vaccine strains. Our results could provide meaningful information to understand comprehensive characteristic of Sea-97 lineage.
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页码：443 / 447
页数：4
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