Chemotherapy related fatal neurotoxicity during induction in acute lymphoblastic leukemia

被引：13

作者：

Ray M. ^{[1
]}

Marwaha R.K. ^{[1
,2
]}

Trehan A. ^{[1
]}

机构：

[1] Div. of Pediat. Hematology-Oncology, Advanced Pediatric Centre, Post Grad. Inst. Med. Educ. and Res., Chandigarh

[2] Div. Pediat. Hematol. - Oncology, Advanced Pediatric Centre, Post Grad. Inst. Med. Educ. and Res.

来源：

The Indian Journal of Pediatrics | 2002年 / 69卷 / 2期

关键词：

Acute leukemia; Chemotherapy; Fatal neurotoxicity;

D O I：

10.1007/BF02859383

中图分类号：

学科分类号：

摘要：

Neurotoxicity is a common complication during cancer chemotherapy. It is estimated that 3-10% of children with acute lymphoblastic leukemia (ALL) experience acute, transient neurotoxicity during induction chemotherapy. Fatal acute neurotoxicity is rarely encountered. Neurological evaluation of children with ALL at diagnosis and during treatment is of value in order to diagnose neurological complications early so that appropriate intervention can be adopted. This communication describes the profile of two children with unexpected, acute fatal neurologic toxicity during induction chemotherapy for ALL.

引用

页码：185 / 187

页数：2

共 17 条

[1]

Craft A.W., Childhood cancer - Mainly curable so where next?, Acta Pediatr, 89, pp. 386-393, (2000)

[2]

Macdonald D.R., Neurologic complications of chemotherapy, Neurol Clin, 9, pp. 955-967, (1991)

[3]

Campbell R.H., Marshall W.C., Chessells J.M., Neurological complications of childhood leukaemia, Arch Dis Child, 52, pp. 850-858, (1977)

[4]

Dimario F.J. Jr., Packer R.J., Acute mental status changes in children with systemic cancer, Pediatrics, 85, pp. 353-360, (1990)

[5]

Mena H., Garcia J.H., Velandia F., Central peripheral myelinopathy associated with systemic neoplasia and chemotherapy, Cancer, 48, pp. 1724-1737, (1981)

[6]

Legha S.S., Vincristine neurotoxicity. Pathophysiology and management, Med Toxicol, 1, pp. 421-427, (1986)

[7]

Sandler S.G., Tobin W., Henderson S., Vincristine induced neuropathy, Neurology, 19, pp. 367-374, (1969)

[8]

McCarthy G.M., Skilling J.R., A prospective cohort study of the orofacial effects of vincristine neurotoxicity, J Oral Pathol, 20, pp. 345-349, (1991)

[9]

Soysal T., Ferhanoglu T., Bilir A., Akman L., Oculomotor nerve palsy associated with vincristine treatment, Acta Haematol, 90, pp. 209-210, (1993)

[10]

Byrd R.L., Rohrbaugh T.M., Raney R.B. Jr., Norris D.G., Transient cortical blindness secondary to vincristine therapy in childhood malignancies, Cancer, 47, pp. 37-40, (1981)

← 1 2 →