Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T)mice

被引:0
作者
Sarah Herdewyn
Carla Cirillo
Ludo Van Den Bosch
Wim Robberecht
Pieter Vanden Berghe
Philip Van Damme
机构
[1] KU Leuven - University of Leuven,Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND)
[2] VIB,Laboratory of Neurobiology
[3] Vesalius Research Center,Department of Neurology
[4] University Hospitals Leuven,Laboratory for Enteric NeuroScience (LENS), Translational Research for Gastrointestinal Disorders (TARGID)
[5] KU Leuven,undefined
来源
Molecular Neurodegeneration | / 9卷
关键词
ALS; TDP43; Gastro-intestinal tract; Neurodegeneration; Enteric nervous system;
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[21]   TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration [J].
Wegorzewska, Iga ;
Bell, Shaughn ;
Cairns, Nigel J. ;
Miller, Timothy M. ;
Baloh, Robert H. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (44) :18809-18814
[22]   A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43 [J].
Lanson, Nicholas A., Jr. ;
Maltare, Astha ;
King, Hanna ;
Smith, Rebecca ;
Kim, Ji Han ;
Taylor, J. Paul ;
Lloyd, Thomas E. ;
Pandey, Udai Bhan .
HUMAN MOLECULAR GENETICS, 2011, 20 (13) :2510-2523
[23]   Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model [J].
Bargsted, Leslie ;
Medinas, Danilo B. ;
Martinez Traub, Francisca ;
Rozas, Pablo ;
Munoz, Natalia ;
Nassif, Melissa ;
Jerez, Carolina ;
Catenaccio, Alejandra ;
Court, Felipe A. ;
Hetz, Claudio ;
Matus, Soledad .
SCIENTIFIC REPORTS, 2017, 7
[24]   Zn2+ modulates in vitro phase separation of TDP-432C and mutant TDP-432C-A315T C-terminal fragments of TDP-43 protein implicated in ALS and FTLD-TDP diseases [J].
Preethi, S. ;
Bharathi, Vidhya ;
Patel, Basant K. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 176 :186-200
[25]   ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice [J].
Horiuchi, Mai ;
Watanabe, Seiji ;
Komine, Okiru ;
Takahashi, Eiki ;
Kaneko, Kumi ;
Itohara, Shigeyoshi ;
Shimada, Mayuko ;
Ogi, Tomoo ;
Yamanaka, Koji .
ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2024, 12 (01)
[26]   An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice [J].
Walker, Adam K. ;
Tripathy, Kalyan ;
Restrepo, Clark R. ;
Ge, Guanghui ;
Xu, Yan ;
Kwong, Linda K. ;
Trojanowski, John Q. ;
Lee, Virginia M. -Y. .
HUMAN MOLECULAR GENETICS, 2015, 24 (25) :7241-7254
[27]   Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models [J].
Marques, Rita F. ;
Engler, Jan B. ;
Kuechler, Katrin ;
Jones, Ross A. ;
Lingner, Thomas ;
Salinas, Gabriela ;
Gillingwater, Thomas H. ;
Friese, Manuel A. ;
Duncan, Kent E. .
HUMAN MOLECULAR GENETICS, 2020, 29 (16) :2647-2661
[28]   Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4 [J].
Girdhar, Amandeep ;
Bharathi, Vidhya ;
Tiwari, Vikas Ramyagya ;
Abhishek, Suman ;
Deeksha, Waghela ;
Mahawar, Usha Saraswat ;
Raju, Gembali ;
Singh, Sandeep Kumar ;
Prabusankar, Ganesan ;
Rajakumara, Eerappa ;
Patel, Basant K. .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 147 :117-130
[29]   A high-fat jelly diet restores bioenergetic balance and extends lifespan in the presence of motor dysfunction and lumbar spinal cord motor neuron loss in TDP-43A315T mutant C57BL6/J mice [J].
Coughlan, Karen S. ;
Halang, Luise ;
Woods, Ina ;
Prehn, Jochen H. M. .
DISEASE MODELS & MECHANISMS, 2016, 9 (09) :1029-1037
[30]   Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction [J].
Gordon, David ;
Dafinca, Ruxandra ;
Scaber, Jakub ;
Alegre-Abarrategui, Javier ;
Farrimond, Lucy ;
Scott, Connor ;
Biggs, Daniel ;
Kent, Louisa ;
Oliver, Peter L. ;
Davies, Benjamin ;
Ansorge, Olaf ;
Wade-Martins, Richard ;
Talbot, Kevin .
NEUROBIOLOGY OF DISEASE, 2019, 121 :148-162