The unfolded protein response

被引：0
作者：
Martin Schröder
机构：
[1] University of Durham,School of Biological and Biomedical Sciences
来源：
Molecular Biotechnology | 2006年 / 34卷
关键词：
Endoplasmic reticulum; molecular chaperone; recombinant protein production; signal transduction; unfolded protein response;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The unfolded protein response (UPR) is a signal transduction network activated by inhibition of protein folding in the endoplasmic reticulum (ER). The UPR coordinates adaptive responses to this stress situation, including induction of ER resident molecular chaperone and protein foldase expression to increase the protein folding capacity of the ER, induction of phospholipid synthesis, attenuation of general translation, and upregulation of ER-associated degradation to decrease the unfolded protein load of the ER, and an antioxidant response. Upon severe or prolonged ER stress the UPR induces apoptosis to eliminate unhealthy cells from an organism or a population. In this review, I will summarize our current knowledge about signal transduction pathways involved in transducing the unfolded protein signal from the ER to the nucleus or the cytosol.
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页码：279 / 290
页数：11
相关论文
共 347 条
[1]  
Schröder M.(2005)ER stress and the unfolded protein response Mutat. Res. 569 29-63
[2]  
Kaufman R. J.(2006)Divergent roles of Ire1α and PERK in the unfolded protein response Curr. Mol. Med. 6 5-36
[3]  
Schröder M.(1993)Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase Cell 73 1197-1206
[4]  
Kaufman R. J.(1993)Atransmembrane protein with a cdc2 Cell 74 743-756
[5]  
Cox J. S.(1999)/CDC28-related kinase activity is required for signaling from the ER to the nucleus Nature 397 271-274
[6]  
Shamu C. E.(2000)Protein translation and folding are coupled by an endoplasmc-reticulum-resident kinase Mol. Cell. Biol. 20 6755-6767
[7]  
Walter P.(2005)ATF6 activated by proteolysis binds in the presence of NFY (CBF) directly to the Nat. Cell Biol. 7 186-194
[8]  
Mori K.(2000)-acting element responsible for the mammalian unfolded protein response Nat. Cell Biol. 2 326-332
[9]  
Ma W.(2002)OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes Dev. Cell 3 99-111
[10]  
Gething M.-J.(2004)Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response J. Biol. Chem. 279 11,345-11,363
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