Basis of Decreased Risk of Gastric Cancer in Severe Atrophic Gastritis with Eradication of Helicobacter pylori

被引：0
作者：
Akira Tari
Yasuhiko Kitadai
Masaharu Sumii
Atsunori Sasaki
Hiroshi Tani
Sinji Tanaka
Kazuaki Chayama
机构：
[1] Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital,Department of Internal Medicine
[2] 1–9-6 Senda-machi,First Department of Internal Medicine
[3] Hiroshima University School of Medicine,undefined
来源：
Digestive Diseases and Sciences | 2007年 / 52卷
关键词：
Gastric atrophy; Intragastric nitrite concentration; Intragastric vitamin C concentration; Polymorphonuclear infiltration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Helicobacter pylori infection induces chronic gastritis and lowers gastric juice ascorbic acid concentrations. We investigated how H. pylori eradication affected multiple variables that could prevent or delay development of new or occult gastric cancer in patients with early gastric cancer treated by endoscopic mucosal resection. Gastric juice pH, nitrite concentrations, and total vitamin C concentrations, serum concentrations of vitamin C and specific H. pylori antibody, and intensity of neutrophil infiltration in gastric mucosa were determined before and after successful H. pylori eradication. Successful eradication increased acid output and ascorbic acid secretion into gastric juice, accompanied by disappearance of polymorphonuclear infiltration from the surface epithelium and decreased gastric juice nitrite concentrations. Our data suggest that H. pylori eradication decreases the nitrosation rate as the ratio of vitamin C to nitrite increases. This decreases reactive oxygen species and nitric oxide, eliminating their damaging effect on DNA and reducing cell turnover.
引用
收藏
页码：232 / 239
页数：7
相关论文
共 229 条
[1]  
Correa P(1992)Human gastric carcinogenesis: a multistep and multifactorial process-first American Cancer Society award lecture on cancer epidemiology and prevention Cancer Res 52 6735-6740
[2]  
Uemura N(1997)Effect of helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer Cancer Epidemiol Biomarkers Prev 6 639-642
[3]  
Mukai T(2000)Atrophy and intestinal metaplasia one year after cure of h. pylori infection: a prospective, randomized study Gastroenterology 119 7-14
[4]  
Okamoto S(1999)Two- to four-year histological follow-up of gastric mucosa after helicobacter pylori eradication J Pathol 188 24-29
[5]  
Yamaguchi S(2002)Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis Aliment pharmacol ther 16 1449-1456
[6]  
Mashiba S(2002)Gastric mucosa: long-term outcome after cure of helicobacter pylori infection J Gastroenterol 37 17-23
[7]  
Taniyama K(2002)Alteration of histological gastritis after cure of helicobacter pylori infection Aliment pharmacol ther 16 1923-1932
[8]  
Sasaki N(2001)Helicobacter pylori infection and the development of gastric cancer N Engl J Med 345 784-789
[9]  
Haruma K(2003)Does intragastric nitrite concentration reflect gastric carcinogenesis in japanese helicobacter pylori-infected patients? Dig dis Sci 95 1730-1736
[10]  
Sumii K(1994)Effect of helicobacter pylori and its eradication on gastric juice ascorbic acid Gut 35 317-322
12345678910