We consider versions of Malliavin calculus on path spaces of compact manifolds with diffusion measures, defining Gross–Sobolev spaces of differentiable functions and proving their intertwining with solution maps, \documentclass[12pt]{minimal}
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\begin{document}$${\mathcal{I}}$$\end{document} , of certain stochastic differential equations. This is shown to shed light on fundamental uniqueness questions for this calculus including uniqueness of the closed derivative operator d and Markov uniqueness of the associated Dirichlet form. A continuity result for the divergence operator by Kree and Kree is extended to this situation. The regularity of conditional expectations of smooth functionals of classical Wiener space, given \documentclass[12pt]{minimal}
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\begin{document}$${\mathcal{I}}$$\end{document} , is considered and shown to have strong implications for these questions. A major role is played by the (possibly sub-Riemannian) connections induced by stochastic differential equations: Damped Markovian connections are used for the covariant derivatives.