Morphological changes in nerve cells during normal aging

被引：0
作者：
Ennio Pannese
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来源：
Brain Structure and Function | 2011年 / 216卷
关键词：
Axons; Dendrites; Dendritic spines; Myelin; Neuron numbers; Synapses;
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摘要：
During normal aging, widespread loss of nerve cells does not occur. Neuronal loss is limited to restricted regions of the nervous system and is slight (probably no more than 10%). The commonest age-related structural changes undergone by nerve cells are as follows: dendrites decrease in number and length and many dendritic spines are lost; axons decrease in number and their myelin sheaths may become less compact and undergo segmental demyelination followed by remyelination; and significant loss of synapses occurs. These changes probably make a significant contribution to the behavioral impairment and cognitive decline that often accompany normal aging.
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页码：85 / 89
页数：4
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