Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms

被引：0
作者：
Jifei Liu
Gang Su
Juan Gao
Ye Tian
Xiaoyan Liu
Zhenchang Zhang
机构：
[1] Lanzhou University Second Hospital,Department of Neurology
[2] Lanzhou University,Institute of Genetics, School of Basic Medical Sciences
来源：
Neurochemical Research | 2020年 / 45卷
关键词：
Peroxiredoxin 2; Neurological disorders; Neuroprotection; Oxidative stress; Neuroinflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Oxidative stress and neuroinflammation are closely related to the pathological processes of neurological disorders. Peroxiredoxin 2 (Prdx2) is an abundant antioxidant enzyme in the central nervous system. Prdx2 reduces the production of reactive oxygen species and participates in regulating various signaling pathways in neurons by catalyzing hydrogen peroxide (H2O2), thereby protecting neurons against oxidative stress and an inflammatory injury. However, the spillage of Prdx2, as damage-associated molecular patterns, accelerates brain damage after stroke by activating an inflammatory response. The post-translational modifications of Prdx2 also affect its enzyme activity. This review focuses on the effects of Prdx2 and its molecular mechanisms in various neurological disorders.
引用
收藏
页码：720 / 730
页数：10
相关论文
共 568 条
[41]  
Tchouague M(2012)Transgenic overexpression of peroxiredoxin-2 attenuates ischemic neuronal injury via suppression of a redox-sensitive pro-death signaling pathway Antioxid Redox Signal 509 110-133
[42]  
Grondin M(2012)Probucol and atorvastatin in combination protect rat brains in MCAO model: upregulating peroxiredoxin2, Foxo3a and Nrf2 expression Neurosci Lett 24 169-112
[43]  
Glory A(2019)Intracerebral hemorrhage-induced brain injury in rats: the role of extracellular peroxiredoxin 2 Transl Stroke Res 967 152-2055
[44]  
Averill-Bates D(2017)Variations in the cerebrospinal fluid proteome following traumatic brain injury and subarachnoid hemorrhage Pathophysiology 14 291-29461
[45]  
Zeida A(2016)The effect of subarachnoid erythrocyte lysate on brain injury: a preliminary study Biosci Rep 658 114-e492
[46]  
Trujillo M(2003)Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders Brain Res 50 119-217
[47]  
Ferrer-Sueta G(2015)Protein drug targets of lavandula angustifolia on treatment of rat Alzheimer's disease Iran J Pharm Res 110 101-63
[48]  
Denicola A(2017)Inhibition of HDAC6 increases acetylation of peroxiredoxin1/2 and ameliorates 6-OHDA induced dopaminergic injury Neurosci Lett 38 2046-1786
[49]  
Estrin DA(2017)Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease Neurobiol Aging 284 29454-3062
[50]  
Radi R(2017)Expression of the antioxidative enzyme peroxiredoxin 2 in multiple sclerosis lesions in relation to inflammation Int J Mol Sci 137 e67-297
12345678910