Effects of Peroxiredoxin 2 in Neurological Disorders: A Review of its Molecular Mechanisms

被引：0
作者：
Jifei Liu
Gang Su
Juan Gao
Ye Tian
Xiaoyan Liu
Zhenchang Zhang
机构：
[1] Lanzhou University Second Hospital,Department of Neurology
[2] Lanzhou University,Institute of Genetics, School of Basic Medical Sciences
来源：
Neurochemical Research | 2020年 / 45卷
关键词：
Peroxiredoxin 2; Neurological disorders; Neuroprotection; Oxidative stress; Neuroinflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Oxidative stress and neuroinflammation are closely related to the pathological processes of neurological disorders. Peroxiredoxin 2 (Prdx2) is an abundant antioxidant enzyme in the central nervous system. Prdx2 reduces the production of reactive oxygen species and participates in regulating various signaling pathways in neurons by catalyzing hydrogen peroxide (H2O2), thereby protecting neurons against oxidative stress and an inflammatory injury. However, the spillage of Prdx2, as damage-associated molecular patterns, accelerates brain damage after stroke by activating an inflammatory response. The post-translational modifications of Prdx2 also affect its enzyme activity. This review focuses on the effects of Prdx2 and its molecular mechanisms in various neurological disorders.
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页码：720 / 730
页数：10
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