Mitochondrial Dysfunction and Molecular Bases of Neurodegenerative Diseases

被引：0
作者：
E. É. Kolesnikova
机构：
[1] National Academy of Sciences of Ukraine,Bogomolets Institute of Physiology
来源：
Neurophysiology | 2013年 / 45卷
关键词：
mitochondria; mitochondrial dysfunction; neurodegenerative diseases; Parkinson’s disease; Alzheimer’s disease; Huntington’s disease; amyotrophic lateral sclerosis; Leigh syndrome; Friedreich’s ataxia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This paper reviews the published data of modern studies, which allow one to summarize the accumulated knowledge on the molecular mechanisms underlying the development of some neurodegenerative diseases and the role of disorders of these mechanisms in the pathogenesis of diseases directly related to the impairments of mitochondrial functions.
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页码：89 / 102
页数：13
相关论文
共 289 条
[1]  
Shadrina MI(2008)Importance of mitochondrial dysfunction and oxidizing injuries in molecular pathology of Parkinson’s disease Mol. Biol. 42 809-819
[2]  
Slominskii PA(2008)Mitochondrial DNA damage and repair in neurodegenerative disorders DNA Repair 7 1110-1120
[3]  
Yang J-L(2007)Primary and secondary mitochondrial insufficiency in neurology and approaches for its correction Cons. Med. 9 105-106
[4]  
Weissman L(2008)Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration Ann. N.Y. Acad. Sci. 1147 283-292
[5]  
Bohr V(2010)Mitochondria: A therapeutic target in neurodegeneration Biochim. Biophys. Acta 1802 212-220
[6]  
Mattson MP(2011)Mitochondrial dysfunction – the beginning of the end in Alzheimer’s disease? Separate and synergistic models of tau and amyloid-β toxicity Alzheimer’s Res. Ther. 3 15-289
[7]  
Illarioshkin SN(2010)Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutation Cell 141 280-275
[8]  
Knott AB(2001)Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria Nat. Genet. 28 272-333
[9]  
Bossy-Wetzel E(1988)Biogenesis of mitochondria Annu. Rev. Cell Biol. 4 289-156
[10]  
Moreira PI(2010)Parkinson’s disease: Exit toxins, enter genetics Prog. Neurobiol. 90 16-192
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