lncRNA-NRF is a Potential Biomarker of Heart Failure After Acute Myocardial Infarction

被引：0
作者：
Li Yan
Yu Zhang
Wei Zhang
Sheng-Qiong Deng
Zhi-Ru Ge
机构：
[1] Ningxia Medical University,Department of Cardiology, Shanghai Gongli Hospital
[2] The Second Military Medical University,Department of Emergency Medicine, Shanghai Gongli Hospital
[3] The Second Military Medical University,Department of Clinical Laboratory, Shanghai Gongli Hospital
[4] The Second Military Medical University,undefined
来源：
Journal of Cardiovascular Translational Research | 2020年 / 13卷
关键词：
Heart failure; Acute myocardial infarction; lncRNA-NRF; Diagnosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Long non-coding RNAs (lncRNAs) are a new focus in cardiovascular diseases. The necrosis-related factor (NRF) is a newly discovered lncRNA, which is increased in myocardial injury. We investigated the role of lncRNA-NRF in heart failure (HF) after acute myocardial infarction (AMI) to find a biomarker for early HF detection. This was a cross-sectional study of 76 AMI patients with HF and 58 AMI patients without HF. lncRNA-NRF was shown to be increased in AMI patients with HF compared with AMI patients without HF and had predictive value for diagnosis of HF. It had a high diagnostic value for HF (AUC, 0.975), while the AUC for N-terminal pro-brain natriuretic peptide was 0.720. Our findings suggest that lncRNA-NRF may represent a marker of risk for development of HF post-AMI.
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页码：1008 / 1015
页数：7
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