Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

被引：0

作者：

Valeriya Lyssenko

Cecilia L F Nagorny

Michael R Erdos

Nils Wierup

Anna Jonsson

Peter Spégel

Marco Bugliani

Richa Saxena

Malin Fex

Nicolo Pulizzi

Bo Isomaa

Tiinamaija Tuomi

Peter Nilsson

Johanna Kuusisto

Jaakko Tuomilehto

Michael Boehnke

David Altshuler

Frank Sundler

Johan G Eriksson

Anne U Jackson

Markku Laakso

Piero Marchetti

Richard M Watanabe

Hindrik Mulder

Leif Groop

机构：

[1] Unit of Diabetes and Endocrinology,Department of Clinical Sciences in Malmoe

[2] Lund University Diabetes Centre,Department of Clinical Sciences in Malmoe

[3] University Hospital,Department of Experimental Medical Science

[4] Unit of Molecular Metabolism,Department of Endocrinology and Metabolism

[5] Lund University Diabetes Centre,Department of Clinical Sciences in Malmoe

[6] Genome Technology Branch,Department of Medicine

[7] National Human Genome Research Institute,Department of Clinical Sciences

[8] Unit of Neuroendocrine Cell Biology,Department of Medicine

[9] Lund University,Department of Health Promotion and Chronic Disease Prevention

[10] University of Pisa,Department of Public Health

[11] Program in Medical and Population Genetics,Department of Biostatistics

[12] Broad Institute of Harvard and Massachusetts Institute of Technology,Department of General Practice and Primary Health Care

[13] Massachusetts General Hospital,Department of Preventive Medicine

[14] Unit for Diabetes and Celiac Disease,Department of Physiology and Biophysics

[15] Lund University Diabetes Centre,undefined

[16] Folkhalsan Research Centre,undefined

[17] Helsinki University Central Hospital,undefined

[18] and Research Program of Molecular Medicine,undefined

[19] University of Helsinki,undefined

[20] Medicine,undefined

[21] Lund University,undefined

[22] University of Kuopio and Kuopio University Hospital,undefined

[23] Diabetes Unit,undefined

[24] National Public Health Institute,undefined

[25] University of Helsinki,undefined

[26] South Ostrobothnia Central Hospital,undefined

[27] Center for Statistical Genetics,undefined

[28] University of Michigan,undefined

[29] Ann Arbor,undefined

[30] National Public Health Institute,undefined

[31] University of Helsinki,undefined

[32] University of Southern California,undefined

[33] Keck School of Medicine,undefined

[34] University of Southern California,undefined

来源：

Nature Genetics | 2009年 / 41卷

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摘要：

Leif Groop and colleagues report that, in prospective studies, a variant in the gene encoding melantonin receptor 1B influences future risk of type 2 diabetes. Insulin release from pancreatic beta cells in response to glucose was inhibited by melatonin.

引用

页码：82 / 88

页数：6

共 50 条

[1] Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Lyssenko, Valeriya
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Erdos, Michael R.
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Jonsson, Anna
Spegel, Peter
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Tuomi, Tiinamaija
Nilsson, Peter
Kuusisto, Johanna
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NATURE GENETICS, 2009, 41 (01) : 82 - 88
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