Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method

被引:0
作者
Sanchita Mandal
Sanat Kumar Basu
Biswanath Sa
机构
[1] Jadavpur University,Division of Pharmaceutics, Department of Pharmaceutical Technology
来源
AAPS PharmSciTech | 2009年 / 10卷
关键词
calcium gluconate; diltiazem hydrochloride; matrix tablet; pH modulator; sodium alginate;
D O I
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中图分类号
学科分类号
摘要
Alginate matrix tablet of diltiazem hydrochloride (DTZ), a water-soluble drug, was prepared using sodium alginate (SAL) and calcium gluconate (CG) by the conventional wet granulation method for sustained release of the drug. The effect of formulation variables like SAL/CG ratio, drug load, microenvironmental pH modulator, and processing variable like compression force on the extent of drug release was examined. The tablets prepared with 1:2 w/w ratio of SAL/CG produced the most sustained release of the drug extending up to 13.5 h. Above and below this ratio, the drug release was faster. The drug load and the hardness of the tablets produced minimal variation in drug release. The addition of alkaline or acidic microenvironmental modulators did not extend the release; instead, these excipients produced somewhat faster release of diltiazem. This study revealed that proper selection of SAL/CG ratio is important to produce alginate matrix tablet by wet granulation method for sustained release of DTZ.
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页码:1348 / 1356
页数:8
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