Resistin - the link between adipose tissue dysfunction and insulin resistance in patients with obstructive sleep apnea

被引：22

作者：

Cherneva R.V. ^{[1
]}

Georgiev O.B. ^{[1
]}

Petrova D.S. ^{[1
]}

Mondeshki T.L. ^{[1
]}

Ruseva S.R. ^{[2
]}

Cakova A.D. ^{[2
]}

Mitev V.I. ^{[2
]}

机构：

[1] Department of Internal Medicine, Division of Pulmonary Medicine, Medical University, Sofia, Sofia 1431

[2] Department of Medical Chemistry and Biochemistry, Laboratory of Synthesis and Analysis of Bioactive Substances, Medical University, Sofia, Sofia 1431

来源：

Journal of Diabetes & Metabolic Disorders | / 12卷 / 1期

关键词：

Diabetes; Impaired glucose tolerance; Insulin resistance; Normal glucose metabolism; OSA; Resistin;

D O I：

10.1186/2251-6581-12-5

中图分类号：

学科分类号：

摘要：

Background: Resistin is an adipocytokine, associated with obesity and inflammation. Its exact role in insulin resistance and diabetes in the general population is still controversial. The relation between resistin plasma levels, insulin resistance and risk of impaired glucose metabolism in OSA patients has not been investigated.Materials and methods: Plasma levels of resistin were measured in 67 patients with OSA and impaired glucose metabolism. 34,7% (23/67) had diabetes; 40% (27/67) patients had impa{cyrillic}ired glucose tolerance(IGT); 25,3%(17/67) had normal glucose metabolism (NGM). The association between resistin, BMI, obesity, markers of insulin resistance, oxidative stress and sleep study characteristics was analysed. The different groups of patients were compared in regards to glucometabolic parameters and biomarkers of oxidative stress - isoprostanes and insulin resistance - free fatty acids (FFA).Results: Plasma levels of resistin were higher in patients with diabetes (6,12 ±5,93ng/ml), compared to those with IGT (3,85±2,81ng/ml, p-0,021) and NGM (3,77±3,23, p-0,043). Resistin did not differ between patients with IGT and NGM (p-0,954). In OSA patients with BMI>40 resistin plasma levels correlated neither to the clinical parameters (BMI, IRI, HOMA-I, HbA1C, AHI, desaturation index), nor to the biomarkers of oxidative stress and insulin resistance. Free fatty acids (0,232>0,177mmol/l, p-0,037) were higher in diabetics in comparison to NGM.Conclusions: Plasma resistin levels in OSA patients with BMI>40 are independent of insulin resistance and are not associated with the parameters, characterising the oxidative stress or severity of OSA. Resistin could be used in a multiple panel of clinical and biomarkers to discern patients with diabetes from those with IGT; in OSA patients with BMI >40 resistin together with HbA1C could discern patients with diabetes from those with NGM. In OSA patients with BMI >40 FFA and HbA1C are useful clinical markers in assessing the risk of dysglycaemia among patients with normal and IGT. © 2013 Cherneva et al.; licensee BioMed Central Ltd.

引用

共 43 条

[1]

Hatipoglu U., Rubinstein I., Inflammation and obstructive sleep apnea syndrome pathogenesis: a working hypothesis, Respiration, 70, pp. 665-671, (2003)

[2]

Tanriverdi H., Evrengul H., Kara C.O., Kuru O., Tanriverdi S., Ozkurt S., Kaftan A., Kilic M., Aortic stiffness, flow-mediated dilatation and carotid intima-media thickness in obstructive sleep apnea: non-invasive indicators of atherosclerosis, Respiration, 73, pp. 741-750, (2006)

[3]

Minoguchi K., Yokoe T., Tazaki T., Minoguchi H., Tanaka A., Oda N., Okada S., Ohta S., Naito H., Adachi M., Increased carotid intima-media thickness and serum inflammatory markers in obstructive sleep apnea, Am J Respir Crit Care Med, 172, pp. 625-630, (2005)

[4]

Ip M.S., Lam B., Ng M.M., Lam W.K., Tsang K.W., Lam K.S., Obstructive sleep apnea is independently associated with insulin resistance, Am J Respir Crit Care Med, 165, pp. 670-676, (2002)

[5]

Punjabi N.M., Shahar E., Redline S., Gottlieb D.J., Givelber R., Resnick H.E., Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study, Am J Epidemiol, 160, pp. 521-530, (2004)

[6]

McArdle N., Hillman D., Beilin L., Watts G., Metabolic risk factors for vascular disease in obstructive sleep apnea: a matched controlled study, Am J Respir Crit Care Med, 175, pp. 190-195, (2007)

[7]

Coughlin S.R., Mawdsley L., Mugarza J.A., Calverley P.M., Wilding J.P., Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome, Eur Heart J, 25, pp. 735-741, (2004)

[8]

Lam J.C., Lam B., Lam C.L., Fong D., Wang J.K., Tse H.F., Lam K.S., Ip M.S., Obstructive sleep apnea and the metabolic syndrome in community- based Chinese adults in Hong Kong, Respir Med, 100, pp. 980-987, (2006)

[9]

Yannakoulia M., Yiannakouris N., Bluher S., Matalas A.L., Klimis-Zacas D., Mantzoros C.S., Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans, J Clin Endocrinol Metab, 88, pp. 1730-1736, (2003)

[10]

Vozarova de Courten B., Degawa-Yamauchi M., Considine R.V., Tataranni P.A., High serum resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima Indians, Diabetes, 53, pp. 1279-1284, (2004)

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