Metastasis of Occult Prostatic Carcinoma to the Sphenoid Sinus: Report of a Rare Case and a Review of the Literature

被引：11
作者：
Fredrik Petersson
Tan Sien Hui
David Loke
Thomas Choudary Putti
机构：
[1] Department of Pathology, National University Health System, Singapore 119074
[2] Department of Oto-Rhino-Laryngology, Khoo Teck Puat Hospital, Singapore
来源：
Head and Neck Pathology | 2012年 / 6卷 / 2期
关键词：
Carcinoma; Metastasis; Occult; Prostatic carcinoma; Sinonasal; Sphenoid sinus;
D O I：
10.1007/s12105-011-0307-6
中图分类号：
学科分类号：
摘要：
We present a case (55-year-old) with a metastasis to the sphenoid sinus from an occult prostatic adenocarcinoma as the first evidence of disease. The patient's symptoms were progressive left-sided headache of a few months duration and a 2-week history of blurred vision with diplopia. Clinical examination revealed a left cranial nerve III palsy and ptosis. A computed tomography scan showed a 2 cm large, well delineated soft tissue lesion involving the left sphenoid sinus and extending to the left cavernous sinus with sclerosis of the adjacent sphenoid bone. Histological and immunohistochemical examinations revealed a poorly differentiated adenocarcinoma that was positive for prostate specific antigen (PSA) and broad-spectrum cytokeratins (Cam 5.2). Subsequent urological examination confirmed a locally advanced prostatic carcinoma with significantly increased serum-PSA (4,561 μg/l) and bone scintigraphy showed widespread metastasis. © 2011 Springer Science+Business Media, LLC.
引用
收藏
页码：258 / 263
页数：5
相关论文
共 42 条
  • [21] Kattah J.C., Chrousos G.C., Roberts J., Et al., Metastatic prostate cancer to the optic canal, Ophthalmology, 100, pp. 1711-1715, (1993)
  • [22] Azana J.M., de Misa R.F., Gomez M.I., Et al., Cutaneous metastases from prostatic cancer, J Dermatol, 20, pp. 786-788, (1993)
  • [23] Singh I., Khaitan A., Diplopia - an unusual primary manifestation of metastatic renal cell carcinoma, Urol Int, 73, pp. 285-286, (2004)
  • [24] Morvan J.B., Veyrieres J.B., Mimouni O., Et al., Clear-cell renal carcinoma metastasis to the base of the tongue and sphenoid sinus: Two very rare atypical ENT locations, Eur Ann Otorhinolaryngol Head Neck Dis, 128, pp. 91-94, (2010)
  • [25] Tanaka K., A case of metastases to the paranasal sinus from rectal mucinous adenocarcinoma, Int J Clin Oncol, 11, pp. 64-65, (2006)
  • [26] Yamasoba T., Kikuchi S., Sugasawa M., Et al., Occult follicular carcinoma metastasizing to the sinonasal tract, ORL J Otorhinolaryngol Relat Spec, 56, pp. 239-243, (1994)
  • [27] Argibay Vazquez S., Lancha Hernandez C., Martinez Muniz A., Metastases in the sphenoidal sinus in a patient with papillary thyroid cancer, Clin Transl Oncol, 7, pp. 324-327, (2005)
  • [28] Ilvan S., Akyildiz E.U., Calay Z., Et al., Endometrial clear cell carcinoma metastatic to the paranasal sinuses: a case report and review of the literature, Gynecol Oncol, 94, pp. 232-234, (2004)
  • [29] Sim R.S., Tan H.K., A case of metastatic hepatocellular carcinoma of the sphenoid sinus, J Laryngol Otol, 108, pp. 503-504, (1994)
  • [30] Aung T.H., Po Y.C., Wong W.K., Hepatocellular carcinoma with metastasis to the skull base, pituitary gland, sphenoid sinus, and cavernous sinus, Hong Kong Med J, 8, pp. 48-51, (2002)
12345