Metastasis of Occult Prostatic Carcinoma to the Sphenoid Sinus: Report of a Rare Case and a Review of the Literature

被引：11
作者：
Fredrik Petersson
Tan Sien Hui
David Loke
Thomas Choudary Putti
机构：
[1] Department of Pathology, National University Health System, Singapore 119074
[2] Department of Oto-Rhino-Laryngology, Khoo Teck Puat Hospital, Singapore
来源：
Head and Neck Pathology | 2012年 / 6卷 / 2期
关键词：
Carcinoma; Metastasis; Occult; Prostatic carcinoma; Sinonasal; Sphenoid sinus;
D O I：
10.1007/s12105-011-0307-6
中图分类号：
学科分类号：
摘要：
We present a case (55-year-old) with a metastasis to the sphenoid sinus from an occult prostatic adenocarcinoma as the first evidence of disease. The patient's symptoms were progressive left-sided headache of a few months duration and a 2-week history of blurred vision with diplopia. Clinical examination revealed a left cranial nerve III palsy and ptosis. A computed tomography scan showed a 2 cm large, well delineated soft tissue lesion involving the left sphenoid sinus and extending to the left cavernous sinus with sclerosis of the adjacent sphenoid bone. Histological and immunohistochemical examinations revealed a poorly differentiated adenocarcinoma that was positive for prostate specific antigen (PSA) and broad-spectrum cytokeratins (Cam 5.2). Subsequent urological examination confirmed a locally advanced prostatic carcinoma with significantly increased serum-PSA (4,561 μg/l) and bone scintigraphy showed widespread metastasis. © 2011 Springer Science+Business Media, LLC.
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页码：258 / 263
页数：5
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