Tamoxifen and fenretinide in women with metastatic breast cancer

被引：0
作者：
J. Zujewski
L. Pai
L. Wakefield
R. Giusti
F.A. Dorr
C. Flanders
R. Caruso
M. Kaiser
L. Goodman
M. Merino
M. Gossard
M.A. Noone
A. Denicoff
D. Venzon
K.H. Cowan
J.A. O'Shaughnessy
机构：
[1] National Cancer Institute,Medicine Branch
[2] National Cancer Institute,Laboratory of Chemoprevention
[3] National Eye Institute,Department of Pathology
[4] National Cancer Institute,Biostatistics and Data Management Section
[5] National Cancer Institute,undefined
来源：
Breast Cancer Research and Treatment | 1999年 / 57卷
关键词：
breast cancer; dark adaptation; fenretinide; lipids; tamoxifen; transforming growth factor‐β;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Tamoxifen and fenretinide combination therapy has been shown to be an active treatment regimen in metastatic breast cancer patients. This pilot study sought to determine whether the addition of fenretinide to tamoxifen would be associated with antitumor activity in metastatic breast cancer patients who had been previously treated with tamoxifen or who had hormone receptor negative disease. The effect of this therapy on circulating plasma transforming growth factor‐beta (TGF‐β) levels and serum lipids was also examined.
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页码：277 / 283
页数：6
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