Synthesis of polymeric thiazolidinediones and L-ascorbic acid towards the development of insulin-sensitizer

Polymers, containing 5-(4-0-methylacryloylbenzyl)thiazolidine-2,4-dione [MABTZD]; poly (MABTZD), poly(MABTZD-co-AA) and poly(MABTZD-co-AMAA), were prepared, and identified by FT-IR,1H-and13C-NMR spectra. The MABTZD unit contents in poly(MABTZD-co-AA) and poly(MABZD-co-AMAA) were 11.3 and 27.7 mol %, respectively. The number average molecular weights of the polymers, as determined by GPC, ranged from 16,800 to 22,300, and with polydispersity indices of 1.2∼1.4.