Retention in care among HIV-infected patients in resource-limited settings: Emerging insights and new directions

被引:217
作者
Geng E.H. [1 ]
Nash D. [1 ]
Kambugu A. [1 ]
Zhang Y. [1 ]
Braitstein P. [1 ]
Christopoulos K.A. [1 ]
Muyindike W. [1 ]
Bwana M.B. [1 ]
Yiannoutsos C.T. [1 ]
Petersen M.L. [1 ]
Martin J.N. [1 ]
机构
[1] Division of HIV, AIDS at San Francisco General Hospital, Building 80, San Francisco, CA 94110
关键词
Access to care; HIV care and treatment; Loss to follow-up; Resource-limited settings; Retention in care;
D O I
10.1007/s11904-010-0061-5
中图分类号
学科分类号
摘要
In resource-limited settings-where a massive scale up of HIV services has occurred in the last 5 years-both understanding the extent of and improving retention in care presents special challenges. First, retention in care within the decentralizing network of services is likely higher than existing estimates that account only for retention in clinic, and therefore antiretroviral therapy services may be more effective than currently believed. Second, both magnitude and determinants of patient retention vary substantially and therefore encouraging the conduct of locally relevant epidemiology is needed to inform programmatic decisions. Third, socio-structural factors such as program characteristics, transportation, poverty, work/child care responsibilities, and social relations are the major determinants of retention in care, and therefore interventions to improve retention in care should focus on implementation strategies. Research to assess and improve retention in care for HIV-infected patients can be strengthened by incorporating novel methods such as sampling-based approaches and a causal analytic framework. © 2010 Springer Science+Business Media, LLC.
引用
收藏
页码:234 / 244
页数:10
相关论文
共 70 条
[1]  
Messeri P.A., Abramson D.M., Aidala A.A., Et al., The impact of ancillary HIV services on engagement in medical care in New York City, AIDS Care, 14, SUPPL. 1, (2002)
[2]  
Kigozi I.M., Dobkin L.M., Martin J.N., Et al., Late-disease stage at presentation to an HIV clinic in the era of free antiretroviral therapy in Sub-Saharan Africa, J Acquir Immune Defic Syndr, 52, pp. 280-289, (2009)
[3]  
Makadzange A.T., Ndhlovu C.E., Takarinda K., Et al., Early versus delayed initiation of antiretroviral therapy for concurrent HIV infection and cryptococcal meningitis in sub-Saharan Africa, Clin Infect Dis, 50, pp. 1532-1538, (2010)
[4]  
Mermin J., Lule J., Ekwaru J.P., Malamba S., Downing R., Ransom R., Kaharuza F., Culver D., Kizito F., Bunnell R., Kigozi A., Nakanjako D., Wafula W., Quick R., Effect of co-trimoxazole prophylaxis on morbidity, mortality, CD4-cell count, and viral load in HIV infection in rural Uganda, Lancet, 364, 9443, pp. 1428-1434, (2004)
[5]  
Bangsberg D.R., Kroetz D.L., Deeks S.G., Adherence-resistance relationships to combination HIV antiretroviral therapy, Current HIV/AIDS Reports, 4, 2, pp. 65-72, (2007)
[6]  
Deeks S.G., Gange S.J., Kitahata M.M., Et al., Trends in multidrug treatment failure and subsequent mortality among antiretroviral therapy-experienced patients with HIV infection in North America, Clin Infect Dis, 49, pp. 1582-1590, (2009)
[7]  
Ware N.C., Idoko J., Kaaya S., Et al., Social Relationships Explain ART Adherence Success in Sub-Saharan Africa: An Account of Resources and Responsibility, (2010)
[8]  
Mills E.J., Nachega J.B., Buchan I., Orbinski J., Attaran A., Singh S., Rachlis B., Wu P., Cooper C., Thabane L., Wilson K., Guyatt G.H., Bangsberg D.R., Adherence to antiretroviral therapy in sub-Saharan Africa and North America: A meta-analysis, Journal of the American Medical Association, 296, 6, pp. 679-690, (2006)
[9]  
Horstmann E., Brown J., Islam F., Et al., Retaining HIV-infected patients in care: Where are we? Where do we go from here?, Clin Infect Dis, 50, pp. 752-761, (2010)
[10]  
Rosen S., Fox M.P., Gill C.J., Patient retention in antiretroviral therapy programs in sub-Saharan Africa: A systematic review, PLoS Medicine, 4, 10, pp. 1691-1701, (2007)