Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus

被引：0
作者：
Akihiro Inui
Hitoshi Ogasawara
Toshio Naito
Iwao Sekigawa
Yoshinari Takasaki
Yasuo Hayashida
Kenji Takamori
Hideoki Ogawa
机构：
[1] Juntendo University School of Medicine,Department of General Medicine
[2] Department of Internal Medicine and Rheumatology,Department of Internal Medicine
[3] Juntendo University Urayasu Hospital,undefined
[4] Institute for Environmental and Gender Specific Medicine,undefined
来源：
Clinical Rheumatology | 2007年 / 26卷
关键词：
Estrogen; Estrogen receptor; RQ-PCR; Systemic lupus erythematosus;
D O I：
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中图分类号：
学科分类号：
摘要：
To investigate the influence of sex hormones on the development of systemic lupus erythematosus (SLE), we examined the estrogen receptor (ER) expression by peripheral blood mononuclear cells (PBMC) in patients with SLE using the real-time quantitative polymerase chain reaction (TaqMan) method. The expression of messenger RNA (mRNA) for ER alpha (ERa) was increased and expression of ER beta (ERb) mRNA was decreased in PBMC from SLE patients compared with PBMC from normal controls. These findings may be useful for elucidation of the pathophysiology of SLE.
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页码：1675 / 1678
页数：3
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