Lipid droplets and the transcriptome of Mycobacterium tuberculosis from direct sputa: a literature review

被引：0
|
作者：
Daniel Mekonnen
Awoke Derbie
Adane Mihret
Solomon Abebe Yimer
Tone Tønjum
Baye Gelaw
Endalkachew Nibret
Abaineh Munshae
Simon J. Waddell
Abraham Aseffa
机构：
[1] Bahir Dar University,Department of Medical Microbiology, College of Medicine and Health Sciences
[2] Bahir Dar University,Institute of Biotechnology
[3] Addis Ababa University,The Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT
[4] Armauer Hansen Research Institute,Africa)
[5] Addis Ababa University,Department of Medical Microbiology, Immunology and Parasitology, College of Medicine and Health Sciences
[6] University of Oslo,Department of Microbiology
[7] Coalition for Epidemic Preparedness Innovations,Department of Microbiology
[8] CEPI,Department of Medical Microbiology, School of Biomedical and Laboratory Sciences
[9] Oslo University Hospital,Department of Biology
[10] College of Medicine and Health Sciences,Department of Global Health and Infection, Brighton and Sussex Medical School
[11] University of Gondar,undefined
[12] Bahir Dar University,undefined
[13] University of Sussex,undefined
来源：
Lipids in Health and Disease | / 20卷
关键词：
Mycobacterium; Sputum; Tuberculosis; Lipid droplet; Transcriptome; Host-pathogen interaction; Transmission; Treatment outcome; Lineage;
D O I：
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学科分类号：
摘要：
Mycobacterium tuberculosis (Mtb), the main etiology of tuberculosis (TB), is predominantly an intracellular pathogen that has caused infection, disease and death in humans for centuries. Lipid droplets (LDs) are dynamic intracellular organelles that are found across the evolutionary tree of life. This review is an evaluation of the current state of knowledge regarding Mtb-LD formation and associated Mtb transcriptome directly from sputa.
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