Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family

被引：0
|
作者：
Y. Ichigotani
S. Matsuda
K. Machida
K. Oshima
T. Iwamoto
K. Yamaki
T. Hayakawa
M. Hamaguchi
机构：
[1] Department of Molecular Pathogenesis,
[2] Nagoya University School of Medicine,undefined
[3] 65 Tsurumai-cho,undefined
[4] Showa-ku,undefined
[5] Nagoya 466-8550,undefined
[6] Japan Tel. +81-52-744-2463; Fax +81-52-735-8167 e-mail: smatsuda@med.nagoya-u.ac.jp,undefined
[7] Second Department of Internal Medicine,undefined
[8] Nagoya University School of Medicine,undefined
[9] Nagoya,undefined
[10] Japan,undefined
[11] Department of Ophthalmology,undefined
[12] Nagoya University School of Medicine,undefined
[13] Nagoya,undefined
[14] Japan,undefined
来源：
Journal of Human Genetics | 2000年 / 45卷
关键词：
Key words SIRP; SHPS-1; Glycoprotein; Chromosome 20p13; RH mapping;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1735 base pairs and has a predicted open reading frame (ORF) encoding 354 amino acids. It possesses a putative signal sequence, a long extracellular domain, a transmembrane region, a short intracellular domain, and no catalytic domain, which is highly homologous to signal-regulatory protein (SIRP)-β, suggesting that it seems to be a new member of the SIRP family. Polymerase chain reaction (PCR)-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 20p13 near the marker D20S906.
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页码：378 / 382
页数：4
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