Interplay between α-synuclein and parkin genes: Insights of Parkinson's disease

被引：6

作者：

Sharma, Kajal ^{[1
]}

Chib, Shivani ^{[1
]}

Gupta, Aniket ^{[1
]}

Singh, Randhir ^{[1
]}

Chalotra, Rishabh ^{[1
]}

机构：

[1] Cent Univ Punjab, Dept Pharmacol, Bathinda 151401, India

来源：

MOLECULAR BIOLOGY REPORTS | 2024年 / 51卷 / 01期

关键词：

Parkinson's disease; alpha-synuclein; Parkin; Neurodegeneration; MITOCHONDRIAL DYSFUNCTION; INCREASED EXPRESSION; BODY FORMATION; CELL-DEATH; PROTEIN; PATHOGENESIS; DOPAMINE; MECHANISMS; NEUROTRANSMISSION; ASSOCIATION;

D O I：

10.1007/s11033-024-09520-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parkinson's disease (PD) is a complex and debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. The pathogenesis of PD is intimately linked to the roles of two key molecular players, alpha-synuclein (alpha-syn) and Parkin. Understanding the intricate interplay between alpha-syn and Parkin is essential for unravelling the molecular underpinnings of PD. Their roles in synaptic function and protein quality control underscore their significance in neuronal health. Dysregulation of these processes, as seen in PD, highlights the potential for targeted therapeutic strategies aimed at restoring normal protein homeostasis and mitigating neurodegeneration. Investigating the connections between alpha-syn, Parkin, and various pathological mechanisms provides insights into the complex web of factors contributing to PD pathogenesis and offers hope for the development of more effective treatments for this devastating neurological disorder. The present compilation provides an overview of their structures, regional and cellular locations, associations, physiological functions, and pathological roles in the context of PD.

引用

页数：15

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