Effects of lithium on platelet membrane phosphoinositides in bipolar disorder patients: a pilot study

被引：0

作者：

J. C. Soares

A. G. Mallinger

C. S. Dippold

K. Forster Wells

E. Frank

D. J. Kupfer

机构：

[1] Department of Psychiatry,

[2] Western Psychiatric Institute and Clinic,undefined

[3] University of Pittsburgh School of Medicine,undefined

[4] Pittsburgh,undefined

[5] Pennsylvania,undefined

[6] USA,undefined

[7] Department of Pharmacology,undefined

[8] University of Pittsburgh School of Medicine,undefined

[9] Pittsburgh,undefined

[10] Pennsylvania,undefined

[11] USA,undefined

[12] Department of Psychology,undefined

[13] University of Pittsburgh,undefined

[14] Pittsburgh,undefined

[15] Pennsylvania,undefined

[16] USA,undefined

[17] Department of Neuroscience,undefined

[18] University of Pittsburgh,undefined

[19] Pittsburgh,undefined

[20] Pennsylvania,undefined

[21] USA,undefined

[22] Neurochemical Brain Imaging Laboratory,undefined

[23] Western Psychiatric Institute and Clinic,undefined

[24] University of Pittsburgh Medical Center,undefined

[25] 3811 O’Hara Street,undefined

[26] Pittsburgh,undefined

[27] PA 15213,undefined

[28] USA e-mail: soares+@pitt.edu,undefined

[29] Fax: +1-412-624-1496,undefined

来源：

Psychopharmacology | 2000年 / 149卷

关键词：

Key words Lithium; Phosphoinositides; Platelet; Bipolar disorder; Signal transduction; Mechanism of action;

D O I：

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中图分类号：

学科分类号：

摘要：

Rationale: In vitro and in vivo animal studies suggest that the intracellular phosphatidylinositol (PI) pathway is an important target for the effects of lithium. Objectives: We conducted a preliminary study to examine the in vivo effects of lithium treatment on platelet membrane phosphoinositides in bipolar disorder subjects, in an attempt to examine further the hypothesis that lithium has significant in vivo effects on the PI pathway in these patients. Methods: We quantitated PI, phosphatidylinositol-4-phosphate (PIP), and phosphatidylinositol-4,5-bisphosphate (PIP2) in platelet membranes of seven subjects (five male, two female; mean age= 27.9±5.7 years), initially while they were unmedicated, and a second time after at least 21 days of lithium treatment (mean±SD=28.7±7.1 days). Results: The mean±SD values for PI were 5.63±2.25% and 5.21±1.06%; for PIP 0.68±0.20% and 0.55±0.11%; and for PIP2 0.60±0.21% and 0.38±0.15%, before and after lithium treatment, respectively. The decrease in PIP2 values after lithium treatment was statistically significant (Wilcoxon signed ranks test, Z=–2.37, P=0.02). Conclusion: This longitudinal study suggests that therapeutic doses of lithium significantly decrease platelet membrane PIP2 levels in vivo in bipolar disorder subjects, which may be related to lithium’s mechanism of action in bipolar disorder.

引用

页码：12 / 16

页数：4