Cholinergic cortical circuits in Parkinson’s disease and in progressive supranuclear palsy: a transcranial magnetic stimulation study

被引：0
作者：
Raffaele Nardone
Igor Florio
Piergiorgio Lochner
Frediano Tezzon
机构：
[1] “F. Tappeiner” Hospital – Merano (BZ),Department of Neurology
来源：
Experimental Brain Research | 2005年 / 163卷
关键词：
Parkinson’s disease; Progressive supranuclear palsy; Transcranial magnetic stimulation; Afferent inhibition; Acetylcholine; Muscarinic receptors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
To investigate the involvement of the cortical cholinergic system in patients with Parkinson’s disease (PD) and with progressive supranuclear palsy (PSP), we performed a comparative study of the short latency afferent inhibition (SAI) in ten patients with PD, in eight patients with PSP and in 15 healthy subjects. Six of the PD patients and four of the PSP patients had dementia. SAI was significantly increased in the PD patients, whereas it was not significantly different between PSP patients and the normal controls. Our findings demonstrate that the excitability of the motor cortex is differentially modulated by sensory afferents in PD and PSP and may indicate that the mechanisms of cholinergic dysfunction are different between the two diseases.
引用
收藏
页码：128 / 131
页数：3
相关论文
共 104 条
  • [1] Albert M(1974)Hypersensitivity of cortical muscarinic receptors in Parkinson’s disease demonstrated by PET J Neurol Neurosurg Psychiatry 37 121-43
  • [2] Asahina H(1995)Subcortical dementia: the neurophysiological evidence Acta Neurol Scand 91 437-387
  • [3] Shinotoh K(1998)Muscarinic receptor blockade has differential effects on the excitability of intracortical circuits in the human motor cortex J Neurol Neurosurg Psychiatry 65 155-513
  • [4] Hirayama T(1988)Noninvasive in vivo assessment of cholinergic cortical circuits in AD using transcranial magnetic stimulation Neuroscience 25 363-397
  • [5] Suhara F(1995)Normal or enhanced short latency afferent inhibition in Parkinson’s disease J Neurol Neurosurg Psychiatry 58 167-262
  • [6] Shishido O(2000)Loss of high-affinity agonist binding to M1 muscarinic receptors in Alzheimer’s disease: implications for the failure of cholinergic replacement therapies Exp Brain Res 523 503-1891
  • [7] Inoue Y(2002)Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer’s disease Neurology 13 392-203
  • [8] Tateno RG(2004)Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson’s disease Brain 127 E8-1185
  • [9] Asahina CD(1991)Heterogeneicity of cognitive impairment in progressive supranuclear palsy, Parkinson’s disease and Alzheimer’s disease Ann Neurol 29 256-170
  • [10] Brown V(1995)The nucleus basalis of Meynert in neurological disease: a quantitative morphological study J Neurochem 64 1888-139
12345678910