ICSI for non-male factor: do we practice what we preach?

Since its introduction in 1992, intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of infertility due to severe male factor. Over the last three decades, the use of ICSI for non-male factor has increased dramatically, despite guidelines to the contrary from professional societies. Excessive utilization of ICSI is primarily due to an irrational fear of total fertilization failure, which is at odds with rational evidence to support its use.