Analgesic and Anti-Inflammatory Activity of Vanillin Derivatives

被引：0
作者：
Yu. A. Boiko
M. V. Nesterkina
A. A. Shandra
I. A. Kravchenko
机构：
[1] Odessa National Medical University,
[2] Odessa National Polytechnic University,undefined
[3] I. I. Mechnikov Odessa National University,undefined
来源：
Pharmaceutical Chemistry Journal | 2019年 / 53卷
关键词：
Vanillin derivatives; TRPA1 and TRPV1 receptors; analgesic activity; anti-inflammatory activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The analgesic activity of 4-hydroxy-3-methoxybenzaldehyde (vanillin) derivatives with different pharmacophore groups were studied in vivo in models of chemically induced pain induced by subplantar administration of the TRP ion channel agonists capsaicin and allylisothiocyanate. The anti-inflammatory actions of vanillin derivatives were demonstrated in a model of carrageenan-induced edema. The analgesic and anti-inflammatory activities of vanillin and its derivatives were studied; these are linked with the effects of these substances on TRPA1 and TRPV1 receptors.
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页码：650 / 654
页数：4
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