RETRACTED ARTICLE: Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer

被引:0
|
作者
Changwei Lin
Yi Zhang
Yifei Chen
Yang Bai
Yi Zhang
机构
[1] The Third XiangYa Hospital of Central South University,Department of Gastrointestinal surgery
[2] Central South University,College of Life Sciences
[3] Affiliated Hospital of Xuzhou Medical University,Department of General Surgery
[4] The Fourth Hospital of Changsha (The Changsha Affiliated Hospital of Hunan Normal University),Department of Otolaryngology
[5] Hunan Normal University,Head Neck Surgery
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Long noncoding RNAs (lncRNAs) have been indicated as important regulators in various human cancers. However, the overall biological roles and clinical significance of most lncRNAs in colon carcinogenesis are not fully understood. Hence, we investigated the clinical significance, biological function and mechanism of LINC01234 in colon cancer. First, we analyzed LINC01234 alterations in colon cancer tissues and corresponding paracancerous tissues through the analysis of sequencing data obtained from The Cancer Genome Atlas and colon cancer patients. Next, we evaluated the effect of LINC01234 on colon cancer cell proliferation and its regulatory mechanism of serine hydroxymethyltransferase 2 (SHMT2) by acting as a competing endogenous RNA (ceRNA). We found that LINC01234 expression was significantly upregulated in colon cancer tissues and was associated with a shorter survival time. Furthermore, the knockdown of LINC01234 induced proliferation arrest via suppressing serine/glycine metabolism. Mechanistic investigations have indicated that LINC01234 functions as a ceRNA for miR-642a-5p, thereby leading to the derepression of its endogenous target serine hydroxymethyltransferase 2 (SHMT2). LINC01234 is significantly overexpressed in colon cancer, and the LINC01234–miR642a-5p–SHMT2 axis plays a critical role in colon cancer proliferation. Our findings may provide a potential new target for colon cancer diagnosis and therapy.
引用
收藏
相关论文
共 50 条
  • [1] RETRACTED ARTICLE: Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer
    Lin, Changwei
    Zhang, Yi
    Chen, Yifei
    Bai, Yang
    CELL DEATH & DISEASE, 2019, 10 (02):
  • [2] RETRACTED: Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer (Retracted Article)
    Lin, Changwei
    Zhang, Yi
    Chen, Yifei
    Bai, Yang
    Zhang, Yi
    CELL DEATH & DISEASE, 2019, 10
  • [3] Retraction Note: Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer
    Changwei Lin
    Yi Zhang
    Yifei Chen
    Yang Bai
    Yi Zhang
    Cell Death & Disease, 14
  • [4] RETRACTION: Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer (Retraction of Vol 10, art no 137, 2019)
    Lin, Changwei
    Zhang, Yi
    Chen, Yifei
    Bai, Yang
    Zhang, Yi
    CELL DEATH & DISEASE, 2023, 14 (07)
  • [5] Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer
    Chen, Xin
    Chen, Zhenyao
    Yu, Shanxun
    Nie, Fengqi
    Yan, Shuai
    Ma, Pei
    Chen, Qinnan
    Wei, Chenchen
    Fu, Hangjiang
    Xu, Tianwei
    Ren, Shengnan
    Sun, Ming
    Wang, Zhaoxia
    CLINICAL CANCER RESEARCH, 2018, 24 (08) : 2002 - 2014
  • [6] Long noncoding RNA LINC01234 promoted cell proliferation and invasion via miR-1284/TRAF6 axis in colorectal cancer
    Liao, Xin
    Zhan, Wei
    Zhang, Jiandong
    Cheng, Zhongsheng
    Li, Lianghe
    Tian, Tian
    Yu, Lei
    Li, Rui
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2020, 121 (10) : 4295 - 4309
  • [7] RETRACTED: Long Noncoding RNA LINC01296 Harbors miR-21a to Regulate Colon Carcinoma Proliferation and Invasion (Retracted Article)
    Wang, Kecheng
    Zhang, Meng
    Wang, Cong
    Ning, Xiaofei
    ONCOLOGY RESEARCH, 2019, 27 (05) : 541 - 549
  • [8] RETRACTED: Long Noncoding RNA LINC00857 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cell through miR-1306/Vimentin Axis (Retracted Article)
    Chang, Na
    Cui, Yayun
    Liang, Xue
    Han, Dan
    Zheng, Xiaomin
    Wu, Ailin
    Qian, Liting
    COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2021, 2021
  • [9] RETRACTED: Downregulation of miR-335-5p by Long Noncoding RNA ZEB1-AS1 in Gastric Cancer Promotes Tumor Proliferation and Invasion (Retracted Article)
    Zhang, Li-li
    Zhang, Lan-fang
    Guo, Xiao-he
    Zhang, De-zhong
    Yang, Fang
    Fan, Ying-ying
    DNA AND CELL BIOLOGY, 2018, 37 (01) : 46 - 52
  • [10] RETRACTED: Long noncoding RNA SNHG14 promotes ovarian cancer cell proliferation and metastasis via sponging miR-219a-5p (Retracted Article)
    Li, L.
    Zhang, R.
    Li, S-J
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (10) : 4136 - 4142