Solitary fibrous tumour of thyroid: Report of two cases with immunohistochemical features and literature review

被引：13

作者：

Santeusanio G. ^{[1
]}

Schiaroli S. ^{[1
]}

Ortenzi A. ^{[1
]}

Mulè A. ^{[2
]}

Perrone G. ^{[3
]}

Fadda G. ^{[2
]}

机构：

[1] Dipartimento di Biopatologia e Diagnostica per Immagini, Sezione di Anatomia Patologica, UOC Anatomia Patologica, Università degli Studi di Roma 'Tor Vergata', Ospedale S. Eugenio - Azienda USL Roma C, 00144 Rome

[2] Istituto di Anatomia e Istologia Patologica, Università Cattolica del Sacro Cuore, 00168 Rome

[3] Anatomia Patologica, Università Campus Bio-Medico, 00155 Rome

来源：

Head and Neck Pathology | 2008年 / 2卷 / 3期

关键词：

Immunohistochemistry; Review; Solitary fibrous tumour; Thyroid;

D O I：

10.1007/s12105-008-0070-5

中图分类号：

学科分类号：

摘要：

Solitary fibrous tumour (SFT) is a rare tumour principally found in adults in the pleural cavity. Extrapleural occurrences are rare. Two cases of SFT of the thyroid gland are described in this paper showing their distinctive microscopical architecture, namely "patternless growth pattern". It is characterized by a bland spindle-cell proliferation alternating hyper- and hypo-cellular areas, keloidlike hyalinization and a focal hemangiopericytoma-like vascular pattern. Tumour cells revealed a diffuse strong positivity for CD34, CD99, bcl-2 and Vimentin, but negativity for Desmin, EMA, AE1/AE3, SMA, S-100 and CD31 antibodies. The differential diagnosis of thyroid SFT includes different types of spindle cell proliferation, benign and malignant mesenchymal tumours, medullary thyroid carcinoma, fasciitis-like papillary carcinoma, and undifferentiated (anaplastic) carcinoma. However, the morphologic and immunohistochemical findings of SFT are so characteristic that this diagnosis seldom represent a difficulty. © Humana 2008.

引用

页码：231 / 235

页数：4

共 30 条

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