β-lactamase-producing bacteria in upper respiratory tract infections

被引：4
作者：
Brook I. [1 ]
机构：
[1] Department of Pediatrics, Georgetown University, School of Medicine, Washington, DC 20016
来源：
Current Infectious Disease Reports | 2010年 / 12卷 / 2期
关键词：
β-lactamase; Anaerobic bacteria; Haemophilus influenzae; Moraxella catarrhalis; Penicillin; Staphylococcus aureus;
D O I：
10.1007/s11908-010-0081-8
中图分类号：
学科分类号：
摘要：
β-Lactamase-producing bacteria (BLPB) can play an important role in respiratory infections. They can have a direct pathogenic impact in causing the infection as well as an indirect effect through their ability to produce the enzyme β-lactamase. BLPB not only may survive penicillin therapy, but as demonstrated by in vitro and in vivo studies, can also protect other penicillin-susceptible bacteria from penicillin by releasing the free enzyme into their environment. The clinical in vitro and in vivo evidence supporting the role of these organisms in the increased failure rate of penicillin in eradication of these infections and the implication of that increased rate on the management of infections is discussed. © The Author(s) 2010.
引用
收藏
页码：110 / 117
页数：7
相关论文
共 70 条
[1]  
Macgowan A.P., BSAC working parties on resistance surveillance: Clinical implications of antimicrobial resistance for therapy, J Antimicrob Chemother, 62, SUPPL. 2, (2008)
[2]  
Harrison C.J., Woods C., Stout G., Et al., Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics, J Antimicrob Chemother, 63, pp. 511-519, (2009)
[3]  
Brook I., Calhoun L., Yocum P., Beta-lactamase-producing isolates of Bacteroides species from children, Antimicrob Agents Chemother, 18, pp. 264-266, (1980)
[4]  
Brook I., The role of beta-lactamase-producing bacteria in the persistence of streptococcal tonsillar infection, Rev Infect Dis, 6, pp. 601-607, (1984)
[5]  
Hackman A.S., Wilkins T.D., In vivo protection of fusobacterium necrophorum from penicillin by bacteroides fragilis, Antimicrob Agents Chemother, 7, pp. 698-703, (1975)
[6]  
Brook I., Pazzaglia G., Coolbaugh J.C., Walker R.I., In-vivo protection of group a - haemolytic streptococci from penicillin by β-lactamase-producing Bacteroides species, Journal of Antimicrobial Chemotherapy, 12, 6, pp. 599-606, (1983)
[7]  
Brook I., Pazzaglia G., Coolbaugh J.C., Walker R.I., In vivo protection of penicillin susceptible bacteroides melaninogenicus from penicillin by facultative bacteria which produce betalactamase, Can J Microbiol, 30, pp. 98-104, (1984)
[8]  
Simon H.M., Sakai W., Staphylococcal antagonism to penicillin-G therapy of hemolytic streptococcal pharyngeal infection. Effect of oxacillin, Pediatrics, 31, pp. 463-469, (1963)
[9]  
Scheifele D.W., Fussell S.J., Frequency of ampicillin resistant haemophilus parainfluenzae in children, J Infect Dis, 143, pp. 495-498, (1981)
[10]  
Brook I., Yokum P., In vitro protection of group A beta-hemolytic streptococci from penicillin and cephalothin by Bacteroides fragilis, Chemotherapy, 29, 1, pp. 18-23, (1983)
1234567