Early effects of fibrin sealant on colonic anastomosis in rats: An experimental and case-control study

被引：36

作者：

Akgün A. ^{[1
]}

Kuru S. ^{[1
]}

Uraldi C. ^{[2
]}

Tekin O. ^{[2
]}

Karip B. ^{[1
]}

Tug T. ^{[1
]}

Öngören A.U. ^{[1
]}

机构：

[1] Second Department of Surgery, Ankara Training and Research Hospital, Ministry of Health, Ankara

[2] Department of Family Medicine, Fatih University, Pursaklar, Ankara

来源：

Techniques in Coloproctology | 2006年 / 10卷 / 3期

关键词：

Colon anastomosis; Fibrin sealant; Hyaluronic acid-carboxymethylcellulose;

D O I：

10.1007/s10151-006-0281-2

中图分类号：

学科分类号：

摘要：

Background: Leakage from colonic anastomoses leads to mortality and morbidity. Fibrin adhesives can be used to increase the strength of the anastomosis. In this study, we evaluated the early effects of fibrin sealant and hyaluronic acid-carboxymethylcellulose on colonic anastomosis in rats. Methods: Anastomoses were carried out in the descending colon of 38 female Wistar-Albino rats, in three groups: control group (n=12), group 1 subjects exposed to hyaluronic acid-carboxymethylcellulose (n=16), and group 2 subjects exposed to fibrin sealant (n=10). After 72 hours, adhesion scores, bursting pressure, rupture strength and histopathologic healing scores were evaluated. Results: Due to postoperative mortality, we evaluated 10, 10 and 9 rats in the control group and in groups 1 and 2, respectively. Of these, we excluded 4, 5 and 4 rats that had macroperforations at autopsy. In the remaining rats, bursting pressure (123.2±14.8 mmHg) and rupture strength (400±16 mg) in the fibrin sealant group were significantly greater than in the two other groups (Control: 68.0±10.6 p=0.006 and 325±52 p=0.009; Group 1: 74.0±9.8 p=0.03, 330±27 p=0.016). However, we did not observe any significant difference between adhesion scores (2.5±0.55, 2.0±0.7, 2.0±0.7, p=0.343). Conclusions: In this experimental study, fibrin sealant increased bursting pressure and rupture strength of colonic anastomoses while hyaluronic acid-carboxymethylcellulose did not have such effetcs in rats. Thus, fibrin sealant may be preferred to decrease the ratio of early leakages from colonic anastomoses.

引用

页码：208 / 214

页数：6

共 43 条

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