Human protein C concentrate in the treatment of purpura fulminans: a retrospective analysis of safety and outcome in 94 pediatric patients

Dreyfus M(1991)Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate N Engl J Med 325 1565-1568

Magny JF(2003)Plasma exchange as a source of protein C for acute-onset protein C pathway failure Br J Haematol 120 167-168

Bridey F(2000)An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia Blood 96 3719-3724

Schwarz HP(1999)Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans Semin Thromb Hemost 25 537-541

Planche C(2005)Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies Crit Care 9 R331-343

Dehan M(2003)Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study Crit Care Med 31 1839-1847

Tchernia G(1977)Anticoagulant properties of bovine plasma protein C following activation by thrombin Biochemistry 16 5824-5831

Baker PM(2001)Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis J Biol Chem 276 11199-11203

Keeling DM(2003)Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nat Med 9 338-342

Murphy M(2002)Activation of endothelial cell protease activated receptor 1 by the protein C pathway Science 296 1880-1882

Dreyfus M(1991)Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate N Engl J Med 325 1565-1568

Magny JF(2003)Plasma exchange as a source of protein C for acute-onset protein C pathway failure Br J Haematol 120 167-168

Bridey F(2000)An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia Blood 96 3719-3724

Schwarz HP(1999)Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans Semin Thromb Hemost 25 537-541

Planche C(2005)Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies Crit Care 9 R331-343

Dehan M(2003)Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study Crit Care Med 31 1839-1847

Tchernia G(1977)Anticoagulant properties of bovine plasma protein C following activation by thrombin Biochemistry 16 5824-5831

Baker PM(2001)Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis J Biol Chem 276 11199-11203

Keeling DM(2003)Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective Nat Med 9 338-342

Murphy M(2002)Activation of endothelial cell protease activated receptor 1 by the protein C pathway Science 296 1880-1882