An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine

被引:0
作者
Jian Wang
Biyan Liang
Xiaoping Zhang
Liran Xu
Xin Deng
Xiuhui Li
Lu Fang
Xinghua Tan
Yuxiang Mao
Guoliang Zhang
Yuguang Wang
机构
[1] China Academy of Chinese Medical Sciences,TCM Center for AIDS Prevention and Treatment
[2] The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,undefined
[3] Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,undefined
[4] Beijing You’an Hospital,undefined
[5] Yunnan Provinical Academy of Traditional Chinese Medicine,undefined
[6] Guangzhou Eighth People’s Hospital,undefined
[7] Hebei Hospital of Traditional Chinese Medicine,undefined
[8] Anhui Hospital of Traditional Chinese Medicine,undefined
[9] Beijing Ditan Hospital,undefined
来源
Frontiers of Medicine | 2014年 / 8卷
关键词
AIDS; HIV; CD4; traditional Chinese medicine; linear models;
D O I
暂无
中图分类号
学科分类号
摘要
This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patients from 19 provinces and cities treated with TCM from 2004 to 2013 was collected. Changes in the indexes of CD4 counts ( ⩽ 200, 201–350, 351–500 and > 500 cells/mm3) at five time points (0, 12, 36, 60 and 84 months) and different treatments [TCM and TCM plus antiretroviral therapy (ART)] were compared. Repeated measures test indicated no interaction between group and time (P > 0.05). Degrees of increasing and decreasing CD4 count of the two groups at four different frames were statistically significant compared with the baseline. The CD4 count between the two groups was not statistically significant. For CD4 count of ⩽ 200 cells/mm3, the mean CD4 count changes were 21 and 28 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 201–350 cells/mm3, the mean CD4 count changes were 6 and 25 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 351–500 cells/mm3, the mean CD4 count changes were −13 and −7 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of > 500 cells/mm3, the mean CD4 count changes were −34 and −17 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. Long-term use of TCM could maintain or slow the pace of declining CD4 counts in patients with HIV/AIDS, and may achieve lasting effectiveness.
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页码:362 / 367
页数:5
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