The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease

被引：75
作者：
Morales-Mantilla D.E. [1 ]
King K.Y. [1 ,2 ]
机构：
[1] Program in Immunology and Center for Cell and Gene Therapy, Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, 77030, TX
[2] Pediatric Infectious Diseases, Baylor College of Medicine, 1102 Bates St. Suite 1150, Houston, 77030, TX
来源：
Current Stem Cell Reports | 2018年 / 4卷 / 3期
基金：
美国国家卫生研究院;
关键词：
Bone marrow; Bone marrow failure; Emergency hematopoiesis; Hematopoietic stem cells; Interferon-gamma; Terminal differentiation;
D O I：
10.1007/s40778-018-0139-3
中图分类号：
学科分类号：
摘要：
Purpose of Review: Interferon-gamma (IFN-γ) is a pro-inflammatory cytokine that participates in the regulation of hematopoietic stem cells (HSC) during development and under homeostatic conditions. IFN-γ also plays a key pathogenic role in several diseases that affect hematopoiesis including aplastic anemia, hemophagocytic lymphohistiocytosis, and cirrhosis of the liver. Recent Findings: Studies have shown that increased IFN-γ negatively affects HSC homeostasis, skewing HSC towards differentiation over self-renewal and eventually causing exhaustion of the HSC compartment. Summary: Here, we explore the mechanisms by which IFN-γ regulates HSC in both normal and pathological conditions. We focus on the role of IFN-γ signaling in HSC fate decisions, and the transcriptional changes it elicits. Elucidating the mechanisms through which IFN-γ regulates HSCs may lead to new therapeutic options to prevent or treat adverse hematologic effects of the many diseases to which IFN-γ contributes. © 2018, The Author(s).
引用
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页码：264 / 271
页数：7
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