Development of Cocaine-Induced Interstitial Lung Damage in Two CYP2C and VKORC1 Variant Allele Carriers

被引：0
作者：
Petal A.H.M. Wijnen
Otto Bekers
Marjolein Drent
机构：
[1] Maastricht University Medical Centre (MUMC),Department of Clinical Chemistry
[2] interstitial lung disease (ild) care consultancy,Department of Respiratory Medicine
[3] MUMC,undefined
来源：
Molecular Diagnosis & Therapy | 2011年 / 15卷
关键词：
Cocaine; Interstitial Lung Disease; Fluorescence Resonance Energy Transfer; Cocaine Abuse; Diffuse Alveolar Hemorrhage;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background: Often, the connection between drug use and the development of related inflammatory damage or idiosyncratic toxicities is hard to recognize and objectify. The presence of cytochrome P450 (CYP) variant genotypes appears to be a substantial susceptibility risk factor in the development of drug-induced pulmonary adverse events. We hypothesized that the presence of variant alleles may be associated with serious complications of illicit drug use.
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页码：177 / 180
页数：3
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