Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary

被引：24
作者：
Ables E.T. [1 ]
Drummond-Barbosa D. [2 ]
机构：
[1] Department of Biology, East Carolina University, Greenville, 27858, NC
[2] Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, 21205, MD
来源：
Current Stem Cell Reports | 2017年 / 3卷 / 1期
基金：
美国国家卫生研究院;
关键词：
Cell fate; Differentiation; Ecdysone; Germ cells; Germline; Nuclear hormone receptor; Oocyte; Oogenesis; Self-renewal;
D O I：
10.1007/s40778-017-0070-z
中图分类号：
学科分类号：
摘要：
Purpose of Review: Stem cells respond to local paracrine signals; more recently, however, systemic hormones have also emerged as key regulators of stem cells. This review explores the role of steroid hormones in stem cells, using the Drosophila germline stem cell as a centerpiece for discussion. Recent Findings: Stem cells sense and respond directly and indirectly to steroid hormones, which regulate diverse sets of target genes via interactions with nuclear hormone receptors. Hormone-regulated networks likely integrate the actions of multiple systemic signals to adjust the activity of stem cell lineages in response to changes in physiological status. Summary: Hormones are inextricably linked to animal physiology and can control stem cells and their local niches. Elucidating the molecular mechanisms of hormone signaling in stem cells is essential for our understanding of the fundamental underpinnings of stem cell biology and for informing new therapeutic interventions against cancers or for regenerative medicine. © 2017, Springer International Publishing AG.
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页码：9 / 18
页数：9
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