Normothermic Machine Preservation of the Liver: State of the Art

被引：29
作者：
Ceresa C.D.L. [1 ]
Nasralla D. [1 ]
Jassem W. [2 ]
机构：
[1] Nuffield Department of Surgical Sciences, University of Oxford, Oxford
[2] Institute of Liver Studies, King’s College Hospital, London
来源：
Current Transplantation Reports | 2018年 / 5卷 / 1期
基金：
英国医学研究理事会;
关键词：
Ischaemia reperfusion injury; Liver transplantation; Normothermic machine perfusion; Organ utilisation;
D O I：
10.1007/s40472-018-0186-9
中图分类号：
学科分类号：
摘要：
Purpose of Review: This review aims to introduce the concept of normothermic machine perfusion (NMP) and its role in liver transplantation. By discussing results from recent clinical studies and highlighting the potential opportunities provided by this technology, we aim to provide a greater insight into NMP and the role it can play to enhance liver transplantation. Recent Findings: NMP has recently been shown to be both safe and feasible in liver transplantation and has also demonstrated its superiority to traditional cold storage in terms of early biochemical liver function. Through the ability to perform a viability assessment during preservation and extend preservation times, it is likely that an increase in organ utilisation will follow. NMP may facilitate the enhanced preservation with improved outcomes from donors after cardiac death and steatotic livers. Furthermore, it provides the exciting potential for liver-directed therapeutic interventions. Summary: Evidence to date suggests that NMP facilitates the enhanced preservation of liver grafts with improved early post-transplant outcomes. The key role for this technology is to increase the number and quality of liver grafts available for transplantation and to reduce waiting list deaths. © 2018, The Author(s).
引用
收藏
页码：104 / 110
页数：6
相关论文
共 51 条
  • [1] Jamieson N.V., Liver preservation: historical review of preservation techniques, Procurement, preservation and allocation of vascularized organs, pp. 159-167, (1997)
  • [2] Carrel A., Lindbergh C.A., The culture of whole organs, Science, 81, 2112, pp. 621-623, (1935)
  • [3] Starzl T.E., Groth C.G., Brettschneider L., Moon J.B., Fulginiti V.A., Cotton E.K., Et al., Extended survival in 3 cases of orthotopic homotransplantation of the human liver, Surgery, 63, 4, pp. 549-563, (1968)
  • [4] Belzer F.O., Ashby B.S., Gulyassy P.F., Powell M., Successful seventeen-hour preservation and transplantation of human-cadaver kidney, N Engl J Med, 278, 11, pp. 608-610, (1968)
  • [5] Neuberger J., Liver transplantation in the United Kingdom, Liver Transpl, 22, 8, pp. 1129-1135, (2016)
  • [6] Kim W.R., Lake J.R., Smith J.M., Skeans M.A., Schladt D.P., Edwards E.B., Et al., OPTN/SRTR 2013 annual data report: liver, Am J Transplant, 15, pp. 1-28, (2015)
  • [7] Lai J.C., Feng S., Roberts J.P., An examination of liver offers to candidates on the liver transplant wait-list, Gastroenterology, 143, 5, pp. 1261-1265, (2012)
  • [8] Hoyer D.P., Paul A., Gallinat A., Molmenti E.P., Reinhardt R., Minor T., Saner F.H., Canbay A., Treckmann J.W., Sotiropoulos G.C., Mathe Z., Donor information based prediction of early allograft dysfunction and outcome in liver transplantation, Liver Int, 35, 1, pp. 156-163, (2015)
  • [9] Foley D.P., Fernandez L.A., Leverson G., Anderson M., Mezrich J., Sollinger H.W., D'Alessandro A., Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single center, Ann Surg, 253, 4, pp. 817-825, (2011)
  • [10] Hassanain M., Simoneau E., Doi S.A., Aljiffry M., Aloraini A., Madkhali A., Metrakos P., Trends in brain-dead organ donor characteristics: a 13-year analysis, Can J Surg, 59, 3, pp. 154-160, (2016)
123456