Evaluation of two fungal exopolysaccharides as potential biomaterials for wound healing applications

被引：0
作者：
Masoud Hamidi
Oseweuba Valentine Okoro
Khodabakhsh Rashidi
Mohammad Saeid Salami
Rasool Mirzaei Seveiri
Hadi Samadian
Amin Shavandi
机构：
[1] Université Libre de Bruxelles (ULB),Department of Medical Biotechnology, Faculty of Paramedicine
[2] Guilan University of Medical Sciences,Research Center of Oils and Fats, Research Institute for Health Technology
[3] Kermanshah University of Medical Sciences,Research Center for Molecular Medicine
[4] Hamadan University of Medical Sciences,undefined
来源：
World Journal of Microbiology and Biotechnology | 2023年 / 39卷
关键词：
Exopolysaccharide (EPS); Scleroglucan; Wound healing;
D O I：
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中图分类号：
学科分类号：
摘要：
Microbial exopolysaccharides (EPSs) are mostly produced by bacteria and fungi and have potential use in the production of biomedical products such as nutraceuticals and in tissue engineering applications. The present study investigated the in vitro biological activities and in vivo wound healing effects of EPSs produced from a Sclerotium-forming fungus (Sclerotium glucanicum DSM 2159) and a yeast (Rhodosporidium babjevae), denoted as scleroglucan (Scl) and EPS-R, respectively. EPS yields of 0.9 ± 0.07 g/L and 1.11 ± 0.4 g/L were obtained from S. glucanicum and R. babjevae, respectively. The physicochemical properties of the EPSs were characterized using infrared spectroscopy and scanning electron microscopy. Further investigations of the biological properties showed that both EPSs were cytocompatible toward the human fibroblast cell line and demonstrated  hemocompatibility. Favorable wound healing capacities of the EPSs (10 mg/mL) were also established via in vivo tests. The present study therefore showed that the EPSs produced by S. glucanicum and R. babjevae have the potential use as biocompatible components for the promotion of dermal wound healing.
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